biostudies-literatureUnknown20(10)Latif MADengue fever (DF), a potentially fatal mosquito-transmitted viral disease caused by dengue virus (DENV) infections (DENVI), stands as the predominant arthropod-borne viral illness worldwide, presenting a significant global health challenge. DENV-mediated proteins/proteases interact with host proteins to develop the infection. Despite the severity of DENVI, the infection-causing host key-genes (hKGs), their pathogenetic processes, and inhibitors/activators are not yet rigorously investigated. This study aimed to disclose DENVI-causing hKGs, highlighting their pathogenetic mechanisms and therapeutic agents. At first, 115 host differentially expressed genes (hDEGs) between DENVI and control samples were identified by employing the LIMMA statistical approach. Through protein-protein interactioPloS onee0333509https://www.ebi.ac.uk/biostudies/studies/S-EPMC12503274biostudies-literatureIn-silico identification of host-key-genes associated with dengue-virus-infections highlighting their pathogenetic mechanisms and therapeutic agents.PMC12503274Hossain MSNoman MANoor TMollah MNHAhmed MFLatif MAAhmmed RPappu MAAKabir MHIslam MSfalseIn-silico identification of host-key-genes associated with dengue-virus-infections highlighting their pathogenetic mechanisms and therapeutic agents.Dengue fever (DF), a potentially fatal mosquito-transmitted viral disease caused by dengue virus (DENV) infections (DENVI), stands as the predominant arthropod-borne viral illness worldwide, presenting a significant global health challenge. DENV-mediated proteins/proteases interact with host proteins to develop the infection. Despite the severity of DENVI, the infection-causing host key-genes (hKGs), their pathogenetic processes, and inhibitors/activators are not yet rigorously investigated. This study aimed to disclose DENVI-causing hKGs, highlighting their pathogenetic mechanisms and therapeutic agents. At first, 115 host differentially expressed genes (hDEGs) between DENVI and control samples were identified by employing the LIMMA statistical approach. Through protein-protein interactio2025-01-01T00:00:00Z20252026-06-04T06:54:07.116Z2026-05-06T03:12:07.887ZS-EPMC125032744105636710.1371/journal.pone.0333509