{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Hymoller KM"],"pubmed_abstract":["<h4>Introduction</h4>The complement system plays a crucial role in bridging innate and adaptive immune responses. When activated, a proteolytic cascade leads to pathogen destruction. It is initiated via the recognition of foreign structures by three pathways: the classical, the lectin, and the alternative. This study focuses on the lectin pathway and the role of four pattern recognition molecules (PRMs), mannan-binding lectin, H-ficolin, L-ficolin, and M-ficolin, in the recognition of microbial patterns and the initiation of complement activation. These PRMs bind to specific carbohydrate structures; each PRM has unique ligand specificities. We investigated the PRM interactions with lipopolysaccharide (LPS) of Gram-negative bacteria.<h4>Methods</h4>Utilizing a microarray of 120 distinct LPS"],"journal":["Journal of innate immunity"],"pagination":["1-27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12503535"],"repository":["biostudies-literature"],"pubmed_title":["Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules MBL and Ficolins of the Complement System."],"pmcid":["PMC12503535"],"pubmed_authors":["Thiel S","Crone L","Hymoller KM","Hennet T"],"additional_accession":[]},"is_claimable":false,"name":"Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules MBL and Ficolins of the Complement System.","description":"<h4>Introduction</h4>The complement system plays a crucial role in bridging innate and adaptive immune responses. When activated, a proteolytic cascade leads to pathogen destruction. It is initiated via the recognition of foreign structures by three pathways: the classical, the lectin, and the alternative. This study focuses on the lectin pathway and the role of four pattern recognition molecules (PRMs), mannan-binding lectin, H-ficolin, L-ficolin, and M-ficolin, in the recognition of microbial patterns and the initiation of complement activation. These PRMs bind to specific carbohydrate structures; each PRM has unique ligand specificities. We investigated the PRM interactions with lipopolysaccharide (LPS) of Gram-negative bacteria.<h4>Methods</h4>Utilizing a microarray of 120 distinct LPS","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-04T06:18:25.4Z","creation":"2026-05-06T03:12:24.954Z"},"accession":"S-EPMC12503535","cross_references":{"pubmed":["40664182"],"doi":["10.1159/000547441"]}}