biostudies-literatureUnknownXiao Y<h4>Introduction</h4>The optimal imaging modality and diagnostic criteria for accurately detecting and characterizing subcentimeter hepatocellular carcinoma (HCC) remain uncertain, and this study aims to compare performance of gadoxetic acid-enhanced MRI (EOB-MRI) and extracellular contrast agent-enhanced MRI (ECA-MRI) in detecting and characterizing subcentimeter HCC.<h4>Methods</h4>A total of 1,022 patients at risk of HCC (mean age, 53.80 ± 11.24, 732 men) with 1,210 subcentimeter hepatic lesions were retrospectively included. Lesion detection rate and HCC characterization performance were calculated and compared between EOB-MRI and ECA-MRI sets using generalized estimating equation method.<h4>Results</h4>Consensually, EOB-MRI demonstrated significantly higher sensitivity for detecting subcentimeter hepatic lesions compared to ECA-MRI (0.995 vs. 0.953, <i>p</i> < 0.001). EOB-MRI and ECA-MRI showed comparable performance in characterizing subcentimeter HCC based on typical vascular pattern (sensitivity, 0.382 vs. 0.457, <i>p</i> = 0.064; specificity 0.941 vs. 0.933, <i>p</i> = 0.462). After applying modified criteria, the sensitivities (EOB-MRI: 0.382 vs. 0.812, <i>p</i> < 0.001; ECA-MRI: 0.457 vs. 0.574, <i>p</i> < 0.001) were significantly increased on both MRIs by consensus reading, while specificities did not differ a lot (EOB-MRI: 0.859 vs. 0.941, <i>p</i> = 0.012; ECA-MRI: 0.894 vs. 0.933, <i>p</i> = 0.084). And compared with ECA-MRI, EOB-MRI exhibited significantly higher sensitivity (0.812 vs. 0.574, <i>p</i> < 0.001) based on modified criteria, without a substantial loss of specificity (0.859 vs. 0.894, <i>p</i> = 0.162).<h4>Conclusion</h4>EOB-MRI with modified criteria exhibited superior detection and characterization performance of subcentimeter HCC when compared with ECA-MRI in patients at risk of HCC, thus offering clinicians more opportunities to accurately identify high-risk subcentimeter lesions.Liver cancerhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12503752biostudies-literatureDetection and Characterization of Subcentimeter Hepatocellular Carcinoma: A Comparison of Gadoxetic Acid-Enhanced and Extracellular Contrast Agent-Enhanced MRI.PMC12503752Liang XWang CZhou CXiao YZeng MJia XWu FWang ZYang CHuang PDai HfalseDetection and Characterization of Subcentimeter Hepatocellular Carcinoma: A Comparison of Gadoxetic Acid-Enhanced and Extracellular Contrast Agent-Enhanced MRI.<h4>Introduction</h4>The optimal imaging modality and diagnostic criteria for accurately detecting and characterizing subcentimeter hepatocellular carcinoma (HCC) remain uncertain, and this study aims to compare performance of gadoxetic acid-enhanced MRI (EOB-MRI) and extracellular contrast agent-enhanced MRI (ECA-MRI) in detecting and characterizing subcentimeter HCC.<h4>Methods</h4>A total of 1,022 patients at risk of HCC (mean age, 53.80 ± 11.24, 732 men) with 1,210 subcentimeter hepatic lesions were retrospectively included. Lesion detection rate and HCC characterization performance were calculated and compared between EOB-MRI and ECA-MRI sets using generalized estimating equation method.<h4>Results</h4>Consensually, EOB-MRI demonstrated significantly higher sensitivity for detecting subcentimeter hepatic lesions compared to ECA-MRI (0.995 vs. 0.953, <i>p</i> < 0.001). EOB-MRI and ECA-MRI showed comparable performance in characterizing subcentimeter HCC based on typical vascular pattern (sensitivity, 0.382 vs. 0.457, <i>p</i> = 0.064; specificity 0.941 vs. 0.933, <i>p</i> = 0.462). After applying modified criteria, the sensitivities (EOB-MRI: 0.382 vs. 0.812, <i>p</i> < 0.001; ECA-MRI: 0.457 vs. 0.574, <i>p</i> < 0.001) were significantly increased on both MRIs by consensus reading, while specificities did not differ a lot (EOB-MRI: 0.859 vs. 0.941, <i>p</i> = 0.012; ECA-MRI: 0.894 vs. 0.933, <i>p</i> = 0.084). And compared with ECA-MRI, EOB-MRI exhibited significantly higher sensitivity (0.812 vs. 0.574, <i>p</i> < 0.001) based on modified criteria, without a substantial loss of specificity (0.859 vs. 0.894, <i>p</i> = 0.162).<h4>Conclusion</h4>EOB-MRI with modified criteria exhibited superior detection and characterization performance of subcentimeter HCC when compared with ECA-MRI in patients at risk of HCC, thus offering clinicians more opportunities to accurately identify high-risk subcentimeter lesions.2025-01-01T00:00:00Z2025 Aug2026-06-04T09:03:18.508Z2026-05-07T03:12:13.008ZS-EPMC125037524106374310.1159/000547751