biostudies-literatureUnknown2025Cabanillas-Lazo M<h4>Introduction</h4>Hyperemesis gravidarum (HG), which is characterized by severe nausea and vomiting, can lead to maternal complications and adverse fetal outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a potentially simple and cost-effective marker for detecting this condition. The aim of this study was to consolidate the current evidence regarding the utility of NLR in diagnosing and assessing the severity of HG.<h4>Methods</h4>A systematic search of Scopus, PubMed, Web of Science, Embase, and Google Scholar was conducted before March 2024. The selected articles were reviewed. Analytical cross-sectional studies reporting NLR values in patients with HG were included. Two independent authors reviewed the articles and assessed them for bias. A meta-analysis with random effects was cJournal of pregnancy4872025https://www.ebi.ac.uk/biostudies/studies/S-EPMC12503971biostudies-literatureLaboratory and Clinical Values of the Neutrophil-to-Lymphocyte Ratio in Women With Hyperemesis Gravidarum: A Systematic Review and Meta-Analysis.PMC12503971Castro-Suarez PMayta-Tovalino FCabanillas-Lazo MUriol-Alvino SFernandez-Navarro MfalseLaboratory and Clinical Values of the Neutrophil-to-Lymphocyte Ratio in Women With Hyperemesis Gravidarum: A Systematic Review and Meta-Analysis.<h4>Introduction</h4>Hyperemesis gravidarum (HG), which is characterized by severe nausea and vomiting, can lead to maternal complications and adverse fetal outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a potentially simple and cost-effective marker for detecting this condition. The aim of this study was to consolidate the current evidence regarding the utility of NLR in diagnosing and assessing the severity of HG.<h4>Methods</h4>A systematic search of Scopus, PubMed, Web of Science, Embase, and Google Scholar was conducted before March 2024. The selected articles were reviewed. Analytical cross-sectional studies reporting NLR values in patients with HG were included. Two independent authors reviewed the articles and assessed them for bias. A meta-analysis with random effects was c2025-01-01T00:00:00Z20252026-06-04T09:02:02.364Z2026-06-01T03:06:47.231ZS-EPMC125039714106420910.1155/jp/4872025