{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Zhou Y"],"pubmed_abstract":["<h4>Background</h4>Abdominal aortic aneurysm (AAA) and Sjögren's syndrome (SS) frequently coexist, suggesting shared pathogenesis, but their genetic-immunological links are unclear.<h4>Objective</h4>Investigate the shared genetic architecture and immune pathways between SS and AAA.<h4>Methods</h4>Using European GWAS summary statistics (SS: 585 cases/1,546 controls; AAA: 4,083 cases/420,324 controls), we applied complementary genomics approaches: LDSC (genetic correlation), S-LDSC (tissue heritability), PLACO/FUMA (pleiotropic loci), MAGMA/Metascape (pathways), SMR (druggable targets), and HyPrColoc (immune cells).<h4>Key results</h4>A significant positive genetic correlation exists (rg = 0.32, PFDR = 0.021). We identified 8 shared risk SNPs and 6 pleiotropic genes (e.g., HLA-B, HLA-DQB2, L"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["1554991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504205"],"repository":["biostudies-literature"],"pubmed_title":["Genetic relationship between Sjogren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis."],"pmcid":["PMC12504205"],"pubmed_authors":["Luo Q","He J","Zhou Y","Ding Z","Xiong H","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Genetic relationship between Sjogren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis.","description":"<h4>Background</h4>Abdominal aortic aneurysm (AAA) and Sjögren's syndrome (SS) frequently coexist, suggesting shared pathogenesis, but their genetic-immunological links are unclear.<h4>Objective</h4>Investigate the shared genetic architecture and immune pathways between SS and AAA.<h4>Methods</h4>Using European GWAS summary statistics (SS: 585 cases/1,546 controls; AAA: 4,083 cases/420,324 controls), we applied complementary genomics approaches: LDSC (genetic correlation), S-LDSC (tissue heritability), PLACO/FUMA (pleiotropic loci), MAGMA/Metascape (pathways), SMR (druggable targets), and HyPrColoc (immune cells).<h4>Key results</h4>A significant positive genetic correlation exists (rg = 0.32, PFDR = 0.021). We identified 8 shared risk SNPs and 6 pleiotropic genes (e.g., HLA-B, HLA-DQB2, L","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-07T03:17:47.438Z","creation":"2026-05-07T03:12:11.035Z"},"accession":"S-EPMC12504205","cross_references":{"pubmed":["41070094"],"doi":["10.3389/fcvm.2025.1554991"]}}