biostudies-literatureUnknown12Zhou Y<h4>Background</h4>Abdominal aortic aneurysm (AAA) and Sjögren's syndrome (SS) frequently coexist, suggesting shared pathogenesis, but their genetic-immunological links are unclear.<h4>Objective</h4>Investigate the shared genetic architecture and immune pathways between SS and AAA.<h4>Methods</h4>Using European GWAS summary statistics (SS: 585 cases/1,546 controls; AAA: 4,083 cases/420,324 controls), we applied complementary genomics approaches: LDSC (genetic correlation), S-LDSC (tissue heritability), PLACO/FUMA (pleiotropic loci), MAGMA/Metascape (pathways), SMR (druggable targets), and HyPrColoc (immune cells).<h4>Key results</h4>A significant positive genetic correlation exists (rg = 0.32, PFDR = 0.021). We identified 8 shared risk SNPs and 6 pleiotropic genes (e.g., HLA-B, HLA-DQB2, LFrontiers in cardiovascular medicine1554991https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504205biostudies-literatureGenetic relationship between Sjogren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis.PMC12504205Luo QHe JZhou YDing ZXiong HWang LfalseGenetic relationship between Sjogren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis.<h4>Background</h4>Abdominal aortic aneurysm (AAA) and Sjögren's syndrome (SS) frequently coexist, suggesting shared pathogenesis, but their genetic-immunological links are unclear.<h4>Objective</h4>Investigate the shared genetic architecture and immune pathways between SS and AAA.<h4>Methods</h4>Using European GWAS summary statistics (SS: 585 cases/1,546 controls; AAA: 4,083 cases/420,324 controls), we applied complementary genomics approaches: LDSC (genetic correlation), S-LDSC (tissue heritability), PLACO/FUMA (pleiotropic loci), MAGMA/Metascape (pathways), SMR (druggable targets), and HyPrColoc (immune cells).<h4>Key results</h4>A significant positive genetic correlation exists (rg = 0.32, PFDR = 0.021). We identified 8 shared risk SNPs and 6 pleiotropic genes (e.g., HLA-B, HLA-DQB2, L2025-01-01T00:00:00Z20252026-05-07T03:17:47.438Z2026-05-07T03:12:11.035ZS-EPMC125042054107009410.3389/fcvm.2025.1554991