{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Godara ML"],"funding":["U.S. Department of Energy","National Institutes of Health","NIH HHS"],"pagination":["34991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Theranostics, a combined approach of diagnostics and therapeutics, often employs F-block therapeutic radionuclides including <sup>225</sup>Ac, <sup>177</sup>Lu, and <sup>161</sup>Tb. While there is a lack of F-block PET imaging radionuclides, the in vivo PET generator pair <sup>140</sup>Nd/<sup>140</sup>Pr can act as a theranostic imaging counterpart to the F-block therapeutic radionuclides. In this study, we explored the production and separation of high purity <sup>140</sup>Nd via the <sup>141</sup>Pr(p,2n)<sup>140</sup>Nd reaction route. Monoisotopic <sup>141</sup>Pr targets irradiated with 20 MeV protons for 10 min with 10 µA beam current yielded 21.45 ± 0.82 MBq (580 ± 22 µCi) of <sup>140</sup>Nd. A two-step separation method was developed for the purification of <sup>140</sup>Nd from"],"journal":["Scientific reports"],"pubmed_title":["Production and radiochemistry of the in vivo PET generator &lt;sup&gt;140&lt;/sup&gt;Nd/&lt;sup&gt;140&lt;/sup&gt;Pr as an imaging surrogate for F-block therapeutic radionuclides."],"pmcid":["PMC12504599"],"funding_grant_id":["DESC0020197","P30CA013148"],"pubmed_authors":["Houson HA","Samuel SL","Godara ML","Cingoranelli SJ","Lapi SE","Tekin V","Saini S"],"additional_accession":[]},"is_claimable":false,"name":"Production and radiochemistry of the in vivo PET generator &lt;sup&gt;140&lt;/sup&gt;Nd/&lt;sup&gt;140&lt;/sup&gt;Pr as an imaging surrogate for F-block therapeutic radionuclides.","description":"Theranostics, a combined approach of diagnostics and therapeutics, often employs F-block therapeutic radionuclides including <sup>225</sup>Ac, <sup>177</sup>Lu, and <sup>161</sup>Tb. While there is a lack of F-block PET imaging radionuclides, the in vivo PET generator pair <sup>140</sup>Nd/<sup>140</sup>Pr can act as a theranostic imaging counterpart to the F-block therapeutic radionuclides. In this study, we explored the production and separation of high purity <sup>140</sup>Nd via the <sup>141</sup>Pr(p,2n)<sup>140</sup>Nd reaction route. Monoisotopic <sup>141</sup>Pr targets irradiated with 20 MeV protons for 10 min with 10 µA beam current yielded 21.45 ± 0.82 MBq (580 ± 22 µCi) of <sup>140</sup>Nd. A two-step separation method was developed for the purification of <sup>140</sup>Nd from","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T05:59:35.549Z","creation":"2026-05-06T03:07:53.065Z"},"accession":"S-EPMC12504599","cross_references":{"pubmed":["41057481"],"doi":["10.1038/s41598-025-18929-4"]}}