{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Hassan SM"],"funding":["National Research Centre Egypt"],"pubmed_abstract":["Spiroindolin-2-ones with phosphonate function 17a‒t (20 analogs, 96‒72% yield) were generated by microwave synthetic methodology using azomethine cycloaddition of the appropriate 3,5-bis(ylidene)-4-piperidone-1-phosphonate 14a‒g. Single crystal X-ray analysis of 17d confirmed the structure. Promising 2D-monolayer antiproliferation properties (MTT assay) were observed for some of the synthesized agents with no harm to normal (RPE1) cell line. Compound 17h (R = 4-ClC<sub>6</sub>H<sub>4</sub>, R' = H; IC<sub>50</sub> = 3.08 μM; 6.6- and 3.1-fold the standard drugs, 5-fluorouracil and sunitinib, respectively) is the most distinguished agent against colon/HCT116 cell line. Compound 17f (R = 4-FC<sub>6</sub>H<sub>4</sub>, R' = Cl; IC<sub>50</sub> = 5.252 μM; 3.2-fold the activity of sunitinib, t"],"journal":["Scientific reports"],"pagination":["35018"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504763"],"repository":["biostudies-literature"],"pubmed_title":["Antiproliferation, 3D-multicellular spheroid and VEGFR-2 inhibitory properties of spiroindolin-2-ones with phosphonate function."],"pmcid":["PMC12504763"],"pubmed_authors":["Hassan SM","Farid A","Nasr S","Kariuki BM","Soliman AAF","Fayad W","Abdelnaser A","Panda SS","Bekheit MS","El-Manawaty MA","Girgis AS"],"additional_accession":[]},"is_claimable":false,"name":"Antiproliferation, 3D-multicellular spheroid and VEGFR-2 inhibitory properties of spiroindolin-2-ones with phosphonate function.","description":"Spiroindolin-2-ones with phosphonate function 17a‒t (20 analogs, 96‒72% yield) were generated by microwave synthetic methodology using azomethine cycloaddition of the appropriate 3,5-bis(ylidene)-4-piperidone-1-phosphonate 14a‒g. Single crystal X-ray analysis of 17d confirmed the structure. Promising 2D-monolayer antiproliferation properties (MTT assay) were observed for some of the synthesized agents with no harm to normal (RPE1) cell line. Compound 17h (R = 4-ClC<sub>6</sub>H<sub>4</sub>, R' = H; IC<sub>50</sub> = 3.08 μM; 6.6- and 3.1-fold the standard drugs, 5-fluorouracil and sunitinib, respectively) is the most distinguished agent against colon/HCT116 cell line. Compound 17f (R = 4-FC<sub>6</sub>H<sub>4</sub>, R' = Cl; IC<sub>50</sub> = 5.252 μM; 3.2-fold the activity of sunitinib, t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T05:59:48.841Z","creation":"2026-05-06T03:07:56.287Z"},"accession":"S-EPMC12504763","cross_references":{"pubmed":["41057507"],"doi":["10.1038/s41598-025-20712-4"]}}