{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Hung KC"],"pubmed_abstract":["<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.<h4>Methods</h4>We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney disea"],"journal":["Frontiers in nutrition"],"pagination":["1653151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504847"],"repository":["biostudies-literature"],"pubmed_title":["Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study."],"pmcid":["PMC12504847"],"pubmed_authors":["Lin YT","Lai YC","Lin CM","Hung KC","Tan PH","Yu TS","Chen IW","Hsu CW","Wang LK"],"additional_accession":[]},"is_claimable":false,"name":"Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.","description":"<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.<h4>Methods</h4>We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney disea","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T09:01:41.457Z","creation":"2026-06-01T03:06:41.396Z"},"accession":"S-EPMC12504847","cross_references":{"pubmed":["41070026"],"doi":["10.3389/fnut.2025.1653151"]}}