biostudies-literatureUnknown12Hung KC<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.<h4>Methods</h4>We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney diseaFrontiers in nutrition1653151https://www.ebi.ac.uk/biostudies/studies/S-EPMC12504847biostudies-literatureZinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.PMC12504847Lin YTLai YCLin CMHung KCTan PHYu TSChen IWHsu CWWang LKfalseZinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.<h4>Methods</h4>We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney disea2025-01-01T00:00:00Z20252026-06-04T09:01:41.457Z2026-06-01T03:06:41.396ZS-EPMC125048474107002610.3389/fnut.2025.1653151