{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gonzalez-Acera M"],"funding":["Deutsche Forschungsgemeinschaft","European Research Council","Volkswagen Foundation","Interdisciplinary Centre for Clinical Research"],"pagination":["1602-1615"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12505074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(10)"],"pubmed_abstract":["<h4>Background</h4>IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance.<h4>Objective</h4>We performed a multimodel transcriptomic analysis of 13 widely used IBD mouse models to uncover coregulatory gene networks conserved between preclinical colitis/ileitis and human IBD and to define model-specific and conserved cellular, subcellular and molecular signatures.<h4>Design</h4>We employed comparative transcriptomic analyses with curated and a priori statistical correlative methods between mouse models versus IBD patient data"],"journal":["Gut"],"pubmed_title":["Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD."],"pmcid":["PMC12505074"],"funding_grant_id":["CRU 5023 (project number 50474582)","531560612","536563567","StG “iMOTIONS” 101078069","418055832","CRC 1340-B06 (project number 372486779)","TRR241 375876048 (A03, A05, A08, B05, Z03)","101078069","A76, A93, J96, and ELAN P120","510624836","KFO5024 505539112 (Project- A3)","CRC 1449-B04 and Z02 (project number 431232613)","SFB1181 (C05)","INST 335/597-1"],"pubmed_authors":["Bacher P","Sanders AD","Bojarski C","Schurmann S","Gunther C","Sturm G","Stolzer I","Gießl A","Lopez-Posadas R","Wang R","Triantafyllopoulou A","Bao LL","Mascia F","Krug SM","Koop K","Gamez-Belmonte R","Gupta P","Wirtz S","Leppkes M","Neufert C","Klose CSN","Schickedanz L","Limberger H","Patankar JV","Dinkel M","Bubeck M","Naschberger E","Atreya I","Schumann M","Diemand L","Plattner C","TRR241 IBDome Consortium","Erkert L","Sturzl M","Romagnani C","Trajanoski Z","Diefenbach A","Pruß MS","Atreya R","Hildner K","Neurath MF","Gerlach K","Gonzalez-Acera M","Cineus R","Britzen-Laurent N","Voskens C","Radbruch A","Siegmund B","Leupold T","Schulzke JD","Waldner M","Scheffold A","Ronchi F","Kuhl AA","Zundler S","Hegazy AN","Ludwig LS","Becker C","Chang HD","Weidinger C","Weigmann B"],"additional_accession":[]},"is_claimable":false,"name":"Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD.","description":"<h4>Background</h4>IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance.<h4>Objective</h4>We performed a multimodel transcriptomic analysis of 13 widely used IBD mouse models to uncover coregulatory gene networks conserved between preclinical colitis/ileitis and human IBD and to define model-specific and conserved cellular, subcellular and molecular signatures.<h4>Design</h4>We employed comparative transcriptomic analyses with curated and a priori statistical correlative methods between mouse models versus IBD patient data","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T07:35:50.998Z","creation":"2026-07-01T03:07:19.473Z"},"accession":"S-EPMC12505074","cross_references":{"pubmed":["40301114"],"doi":["10.1136/gutjnl-2024-333729"]}}