biostudies-literatureGonzalez-Acera MDeutsche ForschungsgemeinschaftEuropean Research CouncilVolkswagen FoundationInterdisciplinary Centre for Clinical Research1602-1615https://www.ebi.ac.uk/biostudies/studies/S-EPMC12505074biostudies-literatureUnknown74(10)<h4>Background</h4>IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance.<h4>Objective</h4>We performed a multimodel transcriptomic analysis of 13 widely used IBD mouse models to uncover coregulatory gene networks conserved between preclinical colitis/ileitis and human IBD and to define model-specific and conserved cellular, subcellular and molecular signatures.<h4>Design</h4>We employed comparative transcriptomic analyses with curated and a priori statistical correlative methods between mouse models versus IBD patient dataGutIntegrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD.PMC12505074CRU 5023 (project number 50474582)531560612536563567StG “iMOTIONS” 101078069418055832CRC 1340-B06 (project number 372486779)TRR241 375876048 (A03, A05, A08, B05, Z03)101078069A76, A93, J96, and ELAN P120510624836KFO5024 505539112 (Project- A3)CRC 1449-B04 and Z02 (project number 431232613)SFB1181 (C05)INST 335/597-1Bacher PSanders ADBojarski CSchurmann SGunther CSturm GStolzer IGießl ALopez-Posadas RWang RTriantafyllopoulou ABao LLMascia FKrug SMKoop KGamez-Belmonte RGupta PWirtz SLeppkes MNeufert CKlose CSNSchickedanz LLimberger HPatankar JVDinkel MBubeck MNaschberger EAtreya ISchumann MDiemand LPlattner CTRR241 IBDome ConsortiumErkert LSturzl MRomagnani CTrajanoski ZDiefenbach APruß MSAtreya RHildner KNeurath MFGerlach KGonzalez-Acera MCineus RBritzen-Laurent NVoskens CRadbruch ASiegmund BLeupold TSchulzke JDWaldner MScheffold ARonchi FKuhl AAZundler SHegazy ANLudwig LSBecker CChang HDWeidinger CWeigmann BfalseIntegrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD.<h4>Background</h4>IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance.<h4>Objective</h4>We performed a multimodel transcriptomic analysis of 13 widely used IBD mouse models to uncover coregulatory gene networks conserved between preclinical colitis/ileitis and human IBD and to define model-specific and conserved cellular, subcellular and molecular signatures.<h4>Design</h4>We employed comparative transcriptomic analyses with curated and a priori statistical correlative methods between mouse models versus IBD patient data2025-01-01T00:00:00Z2025 Sep2026-07-15T07:35:50.998Z2026-07-01T03:07:19.473ZS-EPMC125050744030111410.1136/gutjnl-2024-333729