{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheng Q"],"funding":["The Science and Technology Develoment Fund of Macau SAR:","National Natural Science Foundation of China","Science Foundation Project in Sichuan Province","Innovation Team and Talents Cultivation Program of National Chinese Medicine","Postdoctoral Fellowship Program of CPSF"],"pagination":["e2500446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12506840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(26)"],"pubmed_abstract":["Achieving direct delivery of drugs to the tumor site is a prerequisite for successful drug development, necessitating that drug molecules be cell permeable. Numerous studies have shown that cell-penetrating peptides (CPPs) can augment the efficacy of various therapeutic agents by enhancing cellular uptake, prompting their advancement into preclinical studies. However, the non-specificity and cationic properties of CPPs impede their clinical application. Attributed to the easily accessible capacity and excellent biocompatibility of red blood cells (RBC), herein, an RBC membrane camouflaged, cell-penetrating peptides R8-(RRRRRRRR)based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), thus precisely inducing tum"],"journal":["Advanced healthcare materials"],"pubmed_title":["RBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy."],"pmcid":["PMC12506840"],"funding_grant_id":["81973662","23ZYZYTS0420","0047/2023/AMJ","GZB20230093","ZYYCXTD-D-202209"],"pubmed_authors":["Wang R","Zhang J","Cheng Q","Luo M","He X","Zhong X","Deng L"],"additional_accession":[]},"is_claimable":false,"name":"RBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy.","description":"Achieving direct delivery of drugs to the tumor site is a prerequisite for successful drug development, necessitating that drug molecules be cell permeable. Numerous studies have shown that cell-penetrating peptides (CPPs) can augment the efficacy of various therapeutic agents by enhancing cellular uptake, prompting their advancement into preclinical studies. However, the non-specificity and cationic properties of CPPs impede their clinical application. Attributed to the easily accessible capacity and excellent biocompatibility of red blood cells (RBC), herein, an RBC membrane camouflaged, cell-penetrating peptides R8-(RRRRRRRR)based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), thus precisely inducing tum","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T08:59:01.664Z","creation":"2026-05-07T03:12:43.985Z"},"accession":"S-EPMC12506840","cross_references":{"pubmed":["40331462"],"doi":["10.1002/adhm.202500446"]}}