biostudies-literatureCheng QThe Science and Technology Develoment Fund of Macau SAR:National Natural Science Foundation of ChinaScience Foundation Project in Sichuan ProvinceInnovation Team and Talents Cultivation Program of National Chinese MedicinePostdoctoral Fellowship Program of CPSFe2500446https://www.ebi.ac.uk/biostudies/studies/S-EPMC12506840biostudies-literatureUnknown14(26)Achieving direct delivery of drugs to the tumor site is a prerequisite for successful drug development, necessitating that drug molecules be cell permeable. Numerous studies have shown that cell-penetrating peptides (CPPs) can augment the efficacy of various therapeutic agents by enhancing cellular uptake, prompting their advancement into preclinical studies. However, the non-specificity and cationic properties of CPPs impede their clinical application. Attributed to the easily accessible capacity and excellent biocompatibility of red blood cells (RBC), herein, an RBC membrane camouflaged, cell-penetrating peptides R8-(RRRRRRRR)based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), thus precisely inducing tumAdvanced healthcare materialsRBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy.PMC125068408197366223ZYZYTS04200047/2023/AMJGZB20230093ZYYCXTD-D-202209Wang RZhang JCheng QLuo MHe XZhong XDeng LfalseRBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy.Achieving direct delivery of drugs to the tumor site is a prerequisite for successful drug development, necessitating that drug molecules be cell permeable. Numerous studies have shown that cell-penetrating peptides (CPPs) can augment the efficacy of various therapeutic agents by enhancing cellular uptake, prompting their advancement into preclinical studies. However, the non-specificity and cationic properties of CPPs impede their clinical application. Attributed to the easily accessible capacity and excellent biocompatibility of red blood cells (RBC), herein, an RBC membrane camouflaged, cell-penetrating peptides R8-(RRRRRRRR)based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), thus precisely inducing tum2025-01-01T00:00:00Z2025 Oct2026-06-04T08:59:01.664Z2026-05-07T03:12:43.985ZS-EPMC125068404033146210.1002/adhm.202500446