biostudies-literatureMurayama RNaito FoundationMedical Research Center Initiative for High Depth OmicsTakeda Science FoundationJapan Agency for Medical Research and DevelopmentShinnihon Foundation of Advanced Medical Treatment ResearchMEXT Promotion of Development of a Joint Usage/Research System Project: Coalition of Universities for Research Excellence ProgramUehara Memorial FoundationMEXT Promotion of Development of a Joint Usage/Research System Project: Cooperative Research Project ProgramJapan Society for the Promotion of Sciencee70197https://www.ebi.ac.uk/biostudies/studies/S-EPMC12507397biostudies-literatureUnknown24(10)Aging causes significant changes in gene expression and metabolic function of cells in various organs. Although it is known that liver regeneration is delayed by aging, the effects of aging on changes in gene expression and metabolic functions in liver regeneration need further investigation. In this study, we comprehensively analyzed changes in gene expression and metabolic function by liver regeneration in young and old mice to examine the effects of aging on these changes. During the process of liver regeneration, the gene expression profiles of hepatocytes from young and old mice changed significantly in a stepwise manner while each remained close together. After the completion of liver regeneration, the genes with aging-specific expression patterns in old mouse hepatocytes changed to Aging cellDifferential Effects of Liver Regeneration on Aging-Related Changes in Gene Expression and Metabolic Function.PMC12507397JP19H05267JP19H01177JP22H04698JP24fk0210116JPMXP1323015486JP22H00592JP23K11851JP25H00445JP25fk0210170JP24bm1123005JP23K18579JP25K03454JP21K18039JP22H05634JP23K17199JP18H05102JP20H05040Izumi YSuzuki AMurayama RHorisawa KShu JIshigami KMiura STakahashi MBamba TTaniguchi SfalseDifferential Effects of Liver Regeneration on Aging-Related Changes in Gene Expression and Metabolic Function.Aging causes significant changes in gene expression and metabolic function of cells in various organs. Although it is known that liver regeneration is delayed by aging, the effects of aging on changes in gene expression and metabolic functions in liver regeneration need further investigation. In this study, we comprehensively analyzed changes in gene expression and metabolic function by liver regeneration in young and old mice to examine the effects of aging on these changes. During the process of liver regeneration, the gene expression profiles of hepatocytes from young and old mice changed significantly in a stepwise manner while each remained close together. After the completion of liver regeneration, the genes with aging-specific expression patterns in old mouse hepatocytes changed to 2025-01-01T00:00:00Z2025 Oct2026-06-04T08:47:23.068Z2026-05-07T03:12:15.114ZS-EPMC125073974079386510.1111/acel.70197