biostudies-literatureSoerensen MNational Institute of Health, National Institute on AgingEuropean Union's Seventh Framework ProgrammeNIA NIH HHSFabrikant Vilhelm Pedersen og Hustrus LegatVelux FondenDanish Agency for Science and Higher EducationDanish Agency for Science, Technology and InnovationNovo Nordisk FondenNational Institute on AgingFabrikant Vilhelm Pedersen og Hustrus Legat on recommendation by the Novo Nordisk Foundatione70204https://www.ebi.ac.uk/biostudies/studies/S-EPMC12507416biostudies-literatureUnknown24(10)Osteoporosis is driven by skeletal aging and increases the risk of fragility fractures. Skeletal aging is influenced by epigenetic mechanisms; however, the link to the epigenetic clocks, that is, the suggested biomarkers of biological aging intensively studied within aging research, remains largely unexplored. We investigated the association of eight epigenetic clocks-Horvath, IEAA, Hannum, EEAA, PhenoAge, GrimAge, DunedinPoAm, DunedinPACE-and methylation-based telomere length (mTL) measured at intake (1997, 2007, or 2008-11) with register-based incident fracture and osteoporosis diagnoses in 310 (Discovery cohort), and 777 (Replication cohort) twins, derived from nationwide population-based surveys (end-of-follow-up: 2022). For the 288 youngest twins, bone mineral density (BMD), and bone Aging cellEpigenetic Clocks as Biomarkers for Bone Aging: Evidence From a Twin Study.PMC12507416P01 AG00876109‐063256P01 AG0876109-063256259679NNF21OC0067839Christensen KSoerensen MFigeac FKassem MfalseEpigenetic Clocks as Biomarkers for Bone Aging: Evidence From a Twin Study.Osteoporosis is driven by skeletal aging and increases the risk of fragility fractures. Skeletal aging is influenced by epigenetic mechanisms; however, the link to the epigenetic clocks, that is, the suggested biomarkers of biological aging intensively studied within aging research, remains largely unexplored. We investigated the association of eight epigenetic clocks-Horvath, IEAA, Hannum, EEAA, PhenoAge, GrimAge, DunedinPoAm, DunedinPACE-and methylation-based telomere length (mTL) measured at intake (1997, 2007, or 2008-11) with register-based incident fracture and osteoporosis diagnoses in 310 (Discovery cohort), and 777 (Replication cohort) twins, derived from nationwide population-based surveys (end-of-follow-up: 2022). For the 288 youngest twins, bone mineral density (BMD), and bone 2025-01-01T00:00:00Z2025 Oct2026-06-04T08:48:01.821Z2026-05-07T03:12:31.459ZS-EPMC125074164094730710.1111/acel.70204