{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Di Cintio F"],"funding":["NextGenerationEU"],"pagination":["35128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12508049"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Plastics pose a significant global threat to the ecosystems due to their accumulation and impact on human health. The degradation of plastics results in the formation of microplastics (MPs), small particles less than 5 mm in size, which are released into the environment. Polystyrene (PS) is a major chemical component of plastics, and exposure to PS-based microplastics (PS-MPs) has been linked to cellular damage. This study aimed to explore the effects of 1 μm PS-MPs on human gingival fibroblast cells (hGF). PS-MPs induced a limited cytotoxicity at the tested concentrations and time points. Confocal microscopy, TEM and flow cytometry revealed the uptake of PS-MPs in about 10% of hGF cells. Proteomics identified a profoundly altered proteostasis in PS-MPs treated cells. Enrichment analysis o"],"journal":["Scientific reports"],"pubmed_title":["Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis."],"pmcid":["PMC12508049"],"funding_grant_id":["ECS00000041"],"pubmed_authors":["Di Cintio F","Ronci M","Ruggieri AG","Di Carlo P","Sallese M","De Simone C","Perrotti V"],"additional_accession":[]},"is_claimable":false,"name":"Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis.","description":"Plastics pose a significant global threat to the ecosystems due to their accumulation and impact on human health. The degradation of plastics results in the formation of microplastics (MPs), small particles less than 5 mm in size, which are released into the environment. Polystyrene (PS) is a major chemical component of plastics, and exposure to PS-based microplastics (PS-MPs) has been linked to cellular damage. This study aimed to explore the effects of 1 μm PS-MPs on human gingival fibroblast cells (hGF). PS-MPs induced a limited cytotoxicity at the tested concentrations and time points. Confocal microscopy, TEM and flow cytometry revealed the uptake of PS-MPs in about 10% of hGF cells. Proteomics identified a profoundly altered proteostasis in PS-MPs treated cells. Enrichment analysis o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T09:13:28.875Z","creation":"2026-05-07T03:12:53.111Z"},"accession":"S-EPMC12508049","cross_references":{"pubmed":["41062560"],"doi":["10.1038/s41598-025-19064-w"]}}