{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(10)"],"submitter":["Ubink M"],"funding":["KWF Kankerbestrijding"],"pubmed_abstract":["<h4>Aim</h4>In rectal cancer, neo-adjuvant (chemo)radiotherapy (n(C)RT) should be used selectively, due to related toxicity. The decision to offer n(C)RT is mainly based on preoperative MRI staging. cN category has limited accuracy and its use when deciding on n(C)RT is controversial. This population-based study aimed to assess the association between cN category and local recurrence (LR) rate.<h4>Method</h4>Data from a national cross-sectional cohort of patients who underwent curative resection of primary rectal cancer in the Netherlands in 2016 were used. Patients were subdivided by neo-adjuvant treatment strategy: no n(C)RT, short-course RT with short interval to surgery (SCRT-SI) or downstaging therapy (SCRT with long interval to surgery, CRT, total neoadjuvant therapy or chemotherapy "],"journal":["Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland"],"pagination":["e70257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12508276"],"repository":["biostudies-literature"],"pubmed_title":["Clinical nodal staging to assess the risk of local recurrence after rectal cancer resection: A nationwide cross-sectional study."],"pmcid":["PMC12508276"],"pubmed_authors":["Korving JC","Daniels-Gooszen AW","van der Burg SW","Droogh-de Greve KE","van Breest Smallenburg V","Zandvoort HJA","van Grevenstein WMU","Aalbers AGJ","van den Broek WT","Dinaux AM","Feshtali SS","Bangert F","Nonner J","van Wely BJ","Marsman MS","de Korte FI","Verdaasdonk EGG","Heikens JT","Jou-Valencia D","Kolderman SEM","Masselink I","Roskott-Ten Brinke EA","Duijsens HMH","van der Hul RL","Schreurs WH","van Erp AC","van Dop IM","Polat F","Burghgraef TA","Pereboom ITA","Rothbarth J","Martens MH","Hendriksen EM","van der Hoeven EJRJ","Wybenga JM","van der Sluis M","Schaik HV","Amelung FJ","Nieuwenhuis JF","Geijsen ED","Slooter GD","Verhoef C","Bahadoer RR","Bakker IS","Dogan K","Smits AB","Koster IM","Vermaas M","Qaderi SM","van der Zee D","van der Meij W","van der Sande ME","Janssen P","Wijma AG","Olthof PB","Oosterling SJ","Schuivens PME","Braat MNGJA","de Groot I","Curutchet S","Borstlap WAA","Inberg B","Muller K","de Groof EJ","van Gils RAH","Hoogendoorn S","Renger RJ","Kusters M","Intven MPW","Derksen T","Aukema TS","Scheurkogel MM","Prette JF","Temmink SJD","de Jong CEJ","Neijenhuis PA","Nordkamp S","van Elderen S","Boer AH","Veeken CJ","Krul EJT","Pironet Z","Zorgdrager M","Gielkens H","Fassaert T","Bemelman WA","de Bie SH","van der Wolk S","van den Hoek S","Posma LAE","Tielbeek JAW","Vasbinder GBC","Boerma EG","Bradshaw J","van der Valk MJM","van der Wolf FSW","Beets-Tan RGH","Peeters KCMJ","van Geel AM","van Hoorn F","Ceha HM","Goense L","Ootes D","Demirkiran A","Frietman B","Gerhards MF","Heesink V","Zeilstra AP","de Nes LCF","Beets GL","Crolla RMPH","Paulusma I","van Geffen EGM","van Woerden V","Nielen M","van Westreenen HL","Jonkers J","Noordman BJ","Simons PCG","Rutten HJT","Smalbroek BP","Oppedijk V","de Vries M","Davids PHP","Stoker J","Schasfoort RA","Rutten H","van der Zaag ES","Barendse RM","van Hulst R","Pultrum BB","Rozema T","Keizers B","van Aalten SM","Slob MJ","Plate JDJ","van Landeghem AAG","Vanhooymissen IJS","van Duyn EB","Imani F","Spillenaar-Bilgen EJ","Horsthuis K","Morsink L","Voets S","Verschuur AVD","Braak SJ","Tanis PJ","Lamme B","Stam TC","El-Massoudi Y","Leseman-Hoogenboom MM","de Wit BWK","van Rees JM","Hogewoning A","de Mey DJL","de Lijster MS","Engelbrecht M","Westerterp M","Fabry HFJ","Meijnen P","Blok RD","Krielen P","Dekker JWT","Emmen AMLH","van den Braak RRJC","Dekker EN","Bouwman JE","Kortekaas RTJ","Burger JWA","Moelker-Galuzina J","den Hartogh MD","van Trier D","Govaert MJPM","Peringa J","Avenarius H","Spruit PH","Cnossen JS","Hazen SJA","Krdzalic J","Antonisse IE","Vogelaar FJ","van de Ven AWH","Verduin WM","Poodt IGM","Brandsma ATA","de Haas RJ","Sietses C","Furnee EJB","van den Nieuwboer JBJ","Hogewoning CRC","Sluckin TC","van Koeverden S","Hakkenbrak NAG","Rombouts AJM","Velema LA","Leijtens JWA","Kroese LF","Verrijssen AE","Kok S","Verhagen T","Corver M","Wit F","Roosen LJ","Bisschops RHC","van Egdom LSE","Marijnen CAM","Ankersmit M","Beekhuis HMD","Borstlap J","Ubink M","Hoff C","Wegdam JA","Vroemen JC","van der Velden APS","Rouw DB","Mulder EJ","Vogelij CLA","Boogerd LSF","Talsma AK","van Geloven AAW","Bakers FCH","van Bockel LW","Ketelaers SHJ","Verheijen PM","van Tilborg F","Knops E","Melenhorst J","Lahuis DHH","Schaafsma BE","Vos-Westerman J","den Boer FC","Dunker MS","van Vugt BST","Dutch Snapshot Research Group","Vliegen RFA","Duyck J","Nederend J","Berbee M","Zimmerman DDE","van Essen JA","van Tilborg AAJM","Zheng KJ","Musters GD","The GYM","Eijlers B","Ott P","Tuynman JB","van Westerveld PP","Diederik AL","Feitsma EA","Zamaray B","Woensdregt K","Ashruf JF","Ten Cate DWG","de Wilt JHW"],"additional_accession":[]},"is_claimable":false,"name":"Clinical nodal staging to assess the risk of local recurrence after rectal cancer resection: A nationwide cross-sectional study.","description":"<h4>Aim</h4>In rectal cancer, neo-adjuvant (chemo)radiotherapy (n(C)RT) should be used selectively, due to related toxicity. The decision to offer n(C)RT is mainly based on preoperative MRI staging. cN category has limited accuracy and its use when deciding on n(C)RT is controversial. This population-based study aimed to assess the association between cN category and local recurrence (LR) rate.<h4>Method</h4>Data from a national cross-sectional cohort of patients who underwent curative resection of primary rectal cancer in the Netherlands in 2016 were used. Patients were subdivided by neo-adjuvant treatment strategy: no n(C)RT, short-course RT with short interval to surgery (SCRT-SI) or downstaging therapy (SCRT with long interval to surgery, CRT, total neoadjuvant therapy or chemotherapy ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T09:25:46.574Z","creation":"2026-05-07T03:13:06.836Z"},"accession":"S-EPMC12508276","cross_references":{"pubmed":["41062919"],"doi":["10.1111/codi.70257"]}}