{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Okubo Y"],"funding":["Japan Society for the Promotion of Science"],"pagination":["e70052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12508520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(6)"],"pubmed_abstract":["Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study of 183 biopsy-proven prostate carcinomas (105 with metastatic castration-sensitive prostate carcinoma and 78 non-metastatic high-grade cases) diagnosed between 2017 and 2024. Cribriform pattern, intraductal carcinoma of the prostate, and coagulative tumor necrosis were recorded per core and summarized as patient-level binary status and as semiquantitative proportions per cancer-positive core. Two multivariable logistic regression models (binary and semiquantitative) were fitted, and receiver operating characteristic (ROC) analysis evaluated the discrimin"],"journal":["The journal of pathology. Clinical research"],"pubmed_title":["Cribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease."],"pmcid":["PMC12508520"],"funding_grant_id":["25K10294"],"pubmed_authors":["Aigase T","Washimi K","Kishida T","Yokose T","Yuguchi S","Hiroshima Y","Suzuki A","Yoshioka E","Sato S","Matsuyama R","Miyagi Y","Hasegawa C","Yamamoto Y","Kasajima R","Nakaigawa N","Narimatsu H","Okubo Y"],"additional_accession":[]},"is_claimable":false,"name":"Cribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease.","description":"Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study of 183 biopsy-proven prostate carcinomas (105 with metastatic castration-sensitive prostate carcinoma and 78 non-metastatic high-grade cases) diagnosed between 2017 and 2024. Cribriform pattern, intraductal carcinoma of the prostate, and coagulative tumor necrosis were recorded per core and summarized as patient-level binary status and as semiquantitative proportions per cancer-positive core. Two multivariable logistic regression models (binary and semiquantitative) were fitted, and receiver operating characteristic (ROC) analysis evaluated the discrimin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-04T08:42:43.882Z","creation":"2026-05-07T03:09:14.306Z"},"accession":"S-EPMC12508520","cross_references":{"pubmed":["41063546"],"doi":["10.1002/2056-4538.70052"]}}