biostudies-literatureOkubo YJapan Society for the Promotion of Sciencee70052https://www.ebi.ac.uk/biostudies/studies/S-EPMC12508520biostudies-literatureUnknown11(6)Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study of 183 biopsy-proven prostate carcinomas (105 with metastatic castration-sensitive prostate carcinoma and 78 non-metastatic high-grade cases) diagnosed between 2017 and 2024. Cribriform pattern, intraductal carcinoma of the prostate, and coagulative tumor necrosis were recorded per core and summarized as patient-level binary status and as semiquantitative proportions per cancer-positive core. Two multivariable logistic regression models (binary and semiquantitative) were fitted, and receiver operating characteristic (ROC) analysis evaluated the discriminThe journal of pathology. Clinical researchCribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease.PMC1250852025K10294Aigase TWashimi KKishida TYokose TYuguchi SHiroshima YSuzuki AYoshioka ESato SMatsuyama RMiyagi YHasegawa CYamamoto YKasajima RNakaigawa NNarimatsu HOkubo YfalseCribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease.Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study of 183 biopsy-proven prostate carcinomas (105 with metastatic castration-sensitive prostate carcinoma and 78 non-metastatic high-grade cases) diagnosed between 2017 and 2024. Cribriform pattern, intraductal carcinoma of the prostate, and coagulative tumor necrosis were recorded per core and summarized as patient-level binary status and as semiquantitative proportions per cancer-positive core. Two multivariable logistic regression models (binary and semiquantitative) were fitted, and receiver operating characteristic (ROC) analysis evaluated the discrimin2025-01-01T00:00:00Z2025 Nov2026-06-04T08:42:43.882Z2026-05-07T03:09:14.306ZS-EPMC125085204106354610.1002/2056-4538.70052