biostudies-literatureUnknown24(6)Clifford VThe purpose of this review was to devise a framework for validation studies to test new processing technologies in human milk banking. Human milk banks are an expanding service globally. They provide donor human milk to predominantly preterm and low-birth-weight infants, who represent a vulnerable population. The most common method used by milk banks to ensure the safety of human milk is Holder pasteurization. There has been significant interest in recent years in alternative pathogen inactivation techniques for human milk banking, which may better preserve nutritional content while maintaining an appropriate safety profile. At present, there is no global standard for evaluating and validating new processing technologies for human milk. A major difficulty in developing a standard to evaluaComprehensive reviews in food science and food safetye70288https://www.ebi.ac.uk/biostudies/studies/S-EPMC12508634biostudies-literatureA Framework for Evaluation of New Processing Technologies in Human Milk Banking.PMC12508634Klein LDClifford VWalter LWu TWang YBansal NfalseA Framework for Evaluation of New Processing Technologies in Human Milk Banking.The purpose of this review was to devise a framework for validation studies to test new processing technologies in human milk banking. Human milk banks are an expanding service globally. They provide donor human milk to predominantly preterm and low-birth-weight infants, who represent a vulnerable population. The most common method used by milk banks to ensure the safety of human milk is Holder pasteurization. There has been significant interest in recent years in alternative pathogen inactivation techniques for human milk banking, which may better preserve nutritional content while maintaining an appropriate safety profile. At present, there is no global standard for evaluating and validating new processing technologies for human milk. A major difficulty in developing a standard to evalua2025-01-01T00:00:00Z2025 Nov2026-06-04T08:51:51.533Z2026-05-07T03:12:16.43ZS-EPMC125086344106349010.1111/1541-4337.70288