biostudies-literatureYang YShandong provincial Natural Science Foundation, China416https://www.ebi.ac.uk/biostudies/studies/S-EPMC12509345biostudies-literatureUnknown25(1)<h4>Objective</h4>The triglyceride-glucose (TyG) index and its related parameters are biomarkers of insulin resistance (IR) and maybe of great significance for predicting the occurrence of stroke. This systematic review and meta-analysis aimed to summarize the relationship between TyG and its related parameters with the risks of stroke.<h4>Methods</h4>By searching the Cochrane Library, Embase, and PubMed databases, we obtained prospective cohort studies that reported the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the association between the TyG index and its related parameters (TyG-BMI, TyG-WC, TyG-WHtR) and stroke incidence. The results were combined using a random-effects model.<h4>Results</h4>This meta-analysis included 21 prospective cohort studies with a total ofBMC neurologyAssociation of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.PMC12509345No. ZR2021MH180Sun LYang YBai RMeng MLi BCheng YWang LfalseAssociation of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.<h4>Objective</h4>The triglyceride-glucose (TyG) index and its related parameters are biomarkers of insulin resistance (IR) and maybe of great significance for predicting the occurrence of stroke. This systematic review and meta-analysis aimed to summarize the relationship between TyG and its related parameters with the risks of stroke.<h4>Methods</h4>By searching the Cochrane Library, Embase, and PubMed databases, we obtained prospective cohort studies that reported the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the association between the TyG index and its related parameters (TyG-BMI, TyG-WC, TyG-WHtR) and stroke incidence. The results were combined using a random-effects model.<h4>Results</h4>This meta-analysis included 21 prospective cohort studies with a total of2025-01-01T00:00:00Z2025 Oct2026-06-04T08:44:10.246Z2026-05-07T03:09:20.964ZS-EPMC125093454106868610.1186/s12883-025-04349-4