{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(4)"],"submitter":["Rial C"],"pubmed_abstract":["Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy, mediated by immunoglobulin G (IgG) antibodies targeting platelet factor 4/heparin (PF4/H) complexes. Prompt and accurate diagnosis is critical to ensure appropriate treatment and improve outcomes. We aimed to evaluate the performance of the rapid chemiluminescent immunoassay (CLIA) HemosIL AcuStar HIT-IgG (Werfen) for detecting IgG anti-PF4/H antibodies for HIT diagnosis compared with the Zymutest HIA IgG (Hyphen BioMed) enzyme-linked immunosorbent assay (ELISA). This single-center retrospective cohort included all patients with suspected HIT (4Ts score >3). CLIA and ELISA were performed and compared, and results were evaluated against the serotonin-release assay. We included 113 patients with sus"],"journal":["Blood vessels, thrombosis & hemostasis"],"pagination":["100084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12509767"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of an IgG anti-PF4/H chemiluminescent immunoassay in the diagnosis of heparin-induced thrombocytopenia."],"pmcid":["PMC12509767"],"pubmed_authors":["Piazza J","Sable S","Helley D","Lillo-Le Louet A","Le Beller C","Smadja DM","Rial C","Laney M","Mauge L","Gendron N","Sarthou A","Presot I","Godier A","Diehl JL","Nili R"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of an IgG anti-PF4/H chemiluminescent immunoassay in the diagnosis of heparin-induced thrombocytopenia.","description":"Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy, mediated by immunoglobulin G (IgG) antibodies targeting platelet factor 4/heparin (PF4/H) complexes. Prompt and accurate diagnosis is critical to ensure appropriate treatment and improve outcomes. We aimed to evaluate the performance of the rapid chemiluminescent immunoassay (CLIA) HemosIL AcuStar HIT-IgG (Werfen) for detecting IgG anti-PF4/H antibodies for HIT diagnosis compared with the Zymutest HIA IgG (Hyphen BioMed) enzyme-linked immunosorbent assay (ELISA). This single-center retrospective cohort included all patients with suspected HIT (4Ts score >3). CLIA and ELISA were performed and compared, and results were evaluated against the serotonin-release assay. We included 113 patients with sus","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-04T10:20:12.624Z","creation":"2026-06-04T03:06:04.82Z"},"accession":"S-EPMC12509767","cross_references":{"pubmed":["41080459"],"doi":["10.1016/j.bvth.2025.100084"]}}