biostudies-literatureUnknown5(4)Tang J<h4>Objective</h4>This study aimed to investigate the role of LSM12 in uveal melanoma (UM) oncogenesis and progression, examining its potential as both a prognostic biomarker and therapeutic target.<h4>Methods</h4>LSM12 expression was analyzed in relation to RNA modification genes and tumor stemness in UM. UM cell lines were subjected to LSM12 knockdown using siRNA, followed by cell viability and migration assays. The therapeutic potential of targeting LSM12 was evaluated using a subcutaneous xenograft model. Additionally, the relationship between LSM12 and the PI3K/Akt/mTOR pathway was explored.<h4>Results</h4>LSM12 expression levels were significantly elevated in UM patients, correlating strongly with poor prognosis. Positive correlations were observed between LSM12 expression and multipAdvances in ophthalmology practice and research268-277https://www.ebi.ac.uk/biostudies/studies/S-EPMC12509769biostudies-literatureFunctional characterization of LSM12 as a driver in uveal melanoma oncogenesis.PMC12509769Cheng CLi JAi SRen YChen LZhang PTang JLiu YSu SGao YSun FChen SMao YLu RfalseFunctional characterization of LSM12 as a driver in uveal melanoma oncogenesis.<h4>Objective</h4>This study aimed to investigate the role of LSM12 in uveal melanoma (UM) oncogenesis and progression, examining its potential as both a prognostic biomarker and therapeutic target.<h4>Methods</h4>LSM12 expression was analyzed in relation to RNA modification genes and tumor stemness in UM. UM cell lines were subjected to LSM12 knockdown using siRNA, followed by cell viability and migration assays. The therapeutic potential of targeting LSM12 was evaluated using a subcutaneous xenograft model. Additionally, the relationship between LSM12 and the PI3K/Akt/mTOR pathway was explored.<h4>Results</h4>LSM12 expression levels were significantly elevated in UM patients, correlating strongly with poor prognosis. Positive correlations were observed between LSM12 expression and multip2025-01-01T00:00:00Z2025 Nov-Dec2026-06-04T09:53:54.784Z2026-06-02T03:08:29.624ZS-EPMC125097694108063810.1016/j.aopr.2025.09.001