biostudies-literatureTong XNatural Science Foundation of Yunnan ProvinceNational Natural Science Foundation of ChinaNatural Science Foundation of Yunnan Province (Yunnan Provincial Natural Science Foundation)National Natural Science Foundation of China (National Science Foundation of China)8985https://www.ebi.ac.uk/biostudies/studies/S-EPMC12511331biostudies-literatureUnknown16(1)The streamlined dual-functional group transfer (streamlined dual-FGT) strategy represents an efficient and sustainable approach for difunctionalization reactions, where all atoms or functional groups from the starting materials are fully incorporated into the final products without generating by-products. Pyridine and nitrile functionalities are prevalent and highly valued structural motifs found in a myriad of natural products, pharmaceuticals, agrochemicals, and polymers. The simultaneous incorporation of these groups via the streamlined dual-FGT strategy is thus of considerable significance in synthetic chemistry. Herein, we report a regioselective pyridylcyanation of internal alkynes enabled by an oxalate-based photocatalytic system, employing cyanopyridine as a streamlined dual-functiNature communicationsPhotocatalytic streamlined dual-functional group transfer from cyanopyridine to internal alkynes.PMC1251133122371200202201AT0702052193300522473014Liu YWu JJie JTong XAng HTWang GTian DYuan MSu HYu HfalsePhotocatalytic streamlined dual-functional group transfer from cyanopyridine to internal alkynes.The streamlined dual-functional group transfer (streamlined dual-FGT) strategy represents an efficient and sustainable approach for difunctionalization reactions, where all atoms or functional groups from the starting materials are fully incorporated into the final products without generating by-products. Pyridine and nitrile functionalities are prevalent and highly valued structural motifs found in a myriad of natural products, pharmaceuticals, agrochemicals, and polymers. The simultaneous incorporation of these groups via the streamlined dual-FGT strategy is thus of considerable significance in synthetic chemistry. Herein, we report a regioselective pyridylcyanation of internal alkynes enabled by an oxalate-based photocatalytic system, employing cyanopyridine as a streamlined dual-functi2025-01-01T00:00:00Z2025 Oct2026-06-04T07:41:24.012Z2026-06-01T03:06:28.698ZS-EPMC125113314106813010.1038/s41467-025-64029-2