{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shu K"],"funding":["Natural Science Foundation of Zhejiang Province"],"pagination":["968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12512909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Objective
This study aims to investigate alterations in glymphatic system (GS) function in patients with non-alcoholic fatty liver disease (NAFLD) and explore the relationship of these alterations with cognition and clinical indicators.Materials and methods
In this cross-sectional study, forty-three patients with pre-cirrhotic NAFLD (male: 37, mean age: 38.2 ± 6.7 years) and twenty-three age-, sex-, and education-matched controls (male: 17, mean age: 41.0 ± 6.7 years) underwent diffusion tensor imaging (DTI) examination and cognitive measurements. The DTI analysis along the perivascular space (DTI-ALPS) index, calculated from the DTI data, assessed differences in GS function between the two groups. Linear regression analysis examined the relationship between the ALPS index "],"journal":["BMC psychiatry"],"pubmed_title":["Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS."],"pmcid":["PMC12512909"],"funding_grant_id":["LY18H070003 and LY19H180003"],"pubmed_authors":["Meng S","Liu K","Han L","Wu P","Shu K","Cui S","Zhou Y","Ye X","Song J","Yang Y","Yan Z","Huang X","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS.","description":"Objective
This study aims to investigate alterations in glymphatic system (GS) function in patients with non-alcoholic fatty liver disease (NAFLD) and explore the relationship of these alterations with cognition and clinical indicators.Materials and methods
In this cross-sectional study, forty-three patients with pre-cirrhotic NAFLD (male: 37, mean age: 38.2 ± 6.7 years) and twenty-three age-, sex-, and education-matched controls (male: 17, mean age: 41.0 ± 6.7 years) underwent diffusion tensor imaging (DTI) examination and cognitive measurements. The DTI analysis along the perivascular space (DTI-ALPS) index, calculated from the DTI data, assessed differences in GS function between the two groups. Linear regression analysis examined the relationship between the ALPS index ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T11:00:02.645Z","creation":"2026-05-08T03:10:45.819Z"},"accession":"S-EPMC12512909","cross_references":{"pubmed":["41073924"],"doi":["10.1186/s12888-025-07432-9"]}}