biostudies-literatureO Reilly DRoche PharmaceuticalsTakedaEuropean Union Strengthening the Screening of Lung Cancer in EuropePfizerDepartment of Health, Government of IrelandAstraZenecaIrish Cancer Societye003035https://www.ebi.ac.uk/biostudies/studies/S-EPMC12519366biostudies-literatureUnknown12(1)<h4>Introduction</h4>Low-dose chest CT (LDCT) has demonstrated the ability to detect early-stage lung cancer (LC) and improve disease-specific mortality in high-risk individuals. Use of LC risk scores such as the Prostate, Lung, Colorectal, Ovarian Model Score (PLCO_M2012) improves the sensitivity, specificity and positive predictive value for LC screening. Screening programmes have identified that primary care participation, patient engagement and improved accessibility may enhance the success of LC screening. Currently, there is no LC screening programme in Ireland. This first pilot study of LC screening will investigate (1) the feasibility, including uptake, of LC screening in a community setting, based on primary care-based participant invitation with mobile CT scanning and (BMJ open respiratory researchLung Health Check pilot: Ireland's flagship lung cancer screening trial.PMC12519366NABRCSI23NAIBailey DNaidoo JNoonan CO'Brien EMaguire GEgan KDowling CMRyan DJCounihan ISorensen JRoche SJacob BBaird AMHealy NASulaiman IFitzmaurice GJO Reilly DO'Shea JCotter SDunne JBennett KToomey SHennessy BTRedmond PMorgan RRyan JfalseLung Health Check pilot: Ireland's flagship lung cancer screening trial.<h4>Introduction</h4>Low-dose chest CT (LDCT) has demonstrated the ability to detect early-stage lung cancer (LC) and improve disease-specific mortality in high-risk individuals. Use of LC risk scores such as the Prostate, Lung, Colorectal, Ovarian Model Score (PLCO_M2012) improves the sensitivity, specificity and positive predictive value for LC screening. Screening programmes have identified that primary care participation, patient engagement and improved accessibility may enhance the success of LC screening. Currently, there is no LC screening programme in Ireland. This first pilot study of LC screening will investigate (1) the feasibility, including uptake, of LC screening in a community setting, based on primary care-based participant invitation with mobile CT scanning and (2025-01-01T00:00:00Z2025 Sep2026-07-15T12:19:04.322Z2026-07-04T03:13:11.767ZS-EPMC125193664093556310.1136/bmjresp-2024-003035