{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanches BSF"],"funding":["Núcleo Brasileiro para estudo do Helicobacter pylori e Microbiota"],"pagination":["e70077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12521799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["<h4>Background</h4>The effectiveness of anti-H. pylori treatment diminishes with therapy failure, making regional performance understanding crucial.<h4>Objective</h4>To evaluate the effectiveness of empirical therapy in second-line and subsequent treatments in Brazil.<h4>Methods</h4>A multicenter, prospective, noninterventional registry assessed H. pylori management outcomes by Brazilian gastroenterologists (Hp-BrazilRe, Hp-WorldReg's partner). Data were registered at e-CRF AEG-ReCap from March 2022 to October 2024 and analyzed via modified intention-to-treat (mITT) methodology. Data were subject to quality review.<h4>Results</h4>572 patients (mean age 52 years, 64% women) were included. The primary treatment indications were dyspepsia (64%) and gastroduodenal ulcer (9.2%). Among them, 67%"],"journal":["Helicobacter"],"pubmed_title":["Empirical Rescue Eradication Therapy for Helicobacter pylori Infection in Second and Subsequent Treatment Lines: Experience From 500 Cases of the Brazilian Registry on H. pylori Management (Hp-BrazilReg)."],"pmcid":["PMC12521799"],"funding_grant_id":["01.817.342/0001-61"],"pubmed_authors":["Guedes LR","Hp‐BrazilReg","Burmann BP","Francato MA","Paula RV","Pena LF","Coelho LGV","Barbosa MC","Ribeiro LT","Decanio MA","Ramos AFP","Caetano JS","Marinho JR","Freitas AHA","Couto GC","Vidal MP","Souza HS","Sanches BSF","Alencar CS","Comelli E","Moreira L","Sousa LS","Massote MG","Korman DR","Nyssen OP","Horn M","Loures MTR","Gisbert JP","Bombassaro IZ","Silva LS","Galizzi HO","Breyer HP","Souza TB","Nogueira IM","Cancado GGL","Parra P","Kuniyoshi ASO","Marinho FP","Veloso JS","Okamoto H","Chinzon D","Passos MCF","Chaves SR","Poncinelli CS","Cano-Catala A","Goncalves JN","Terra DAA","Silva LL","Mantovani A","Domingues AG","Barbosa JG"],"additional_accession":[]},"is_claimable":false,"name":"Empirical Rescue Eradication Therapy for Helicobacter pylori Infection in Second and Subsequent Treatment Lines: Experience From 500 Cases of the Brazilian Registry on H. pylori Management (Hp-BrazilReg).","description":"<h4>Background</h4>The effectiveness of anti-H. pylori treatment diminishes with therapy failure, making regional performance understanding crucial.<h4>Objective</h4>To evaluate the effectiveness of empirical therapy in second-line and subsequent treatments in Brazil.<h4>Methods</h4>A multicenter, prospective, noninterventional registry assessed H. pylori management outcomes by Brazilian gastroenterologists (Hp-BrazilRe, Hp-WorldReg's partner). Data were registered at e-CRF AEG-ReCap from March 2022 to October 2024 and analyzed via modified intention-to-treat (mITT) methodology. Data were subject to quality review.<h4>Results</h4>572 patients (mean age 52 years, 64% women) were included. The primary treatment indications were dyspepsia (64%) and gastroduodenal ulcer (9.2%). Among them, 67%","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep-Oct","modification":"2026-06-04T12:06:12.172Z","creation":"2026-05-09T03:07:55.067Z"},"accession":"S-EPMC12521799","cross_references":{"pubmed":["41088538"],"doi":["10.1111/hel.70077"]}}