biostudies-literatureUnknown8(10)Ho D<h4>Importance</h4>Donation-based prosocial interventions involve someone receiving a free health service and then distributing or donating to support health services for others; examples within the HIV and sexually transmitted infection (STI) literature include secondary distribution of HIV self-tests, secondary syringe exchange, and pay it forward for STI testing. These interventions answer research and policy recommendations to incorporate prosocial behaviors into HIV/STI services.<h4>Objective</h4>To describe motivations, facilitators, and barriers of donation-based interventions in HIV and STI research using data from qualitative studies.<h4>Evidence review</h4>In this systematic review, 5 databases (PubMed, CINAHL, Embase, PsycInfo, and Scopus) and references were searched up to JanuJAMA network opene2537382https://www.ebi.ac.uk/biostudies/studies/S-EPMC12522005biostudies-literatureMotivations, Facilitators, and Barriers of Donation-Based Interventions in HIV and Sexually Transmitted Infection Research: A Systematic Review.PMC12522005Conklin JDay STucker JDFitzpatrick THo DRamaswamy RHlatshwako TGWang JWang RCLiu YKpokiri EEGeng ETang WfalseMotivations, Facilitators, and Barriers of Donation-Based Interventions in HIV and Sexually Transmitted Infection Research: A Systematic Review.<h4>Importance</h4>Donation-based prosocial interventions involve someone receiving a free health service and then distributing or donating to support health services for others; examples within the HIV and sexually transmitted infection (STI) literature include secondary distribution of HIV self-tests, secondary syringe exchange, and pay it forward for STI testing. These interventions answer research and policy recommendations to incorporate prosocial behaviors into HIV/STI services.<h4>Objective</h4>To describe motivations, facilitators, and barriers of donation-based interventions in HIV and STI research using data from qualitative studies.<h4>Evidence review</h4>In this systematic review, 5 databases (PubMed, CINAHL, Embase, PsycInfo, and Scopus) and references were searched up to Janu2025-01-01T00:00:00Z2025 Oct2026-06-04T10:33:20.612Z2026-06-02T03:08:04.159ZS-EPMC125220054108598510.1001/jamanetworkopen.2025.37382