{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Browning SE"],"pubmed_abstract":["<i>Mycobacterium tuberculosis</i> (Mtb) and HIV are leading infectious causes of death worldwide and act synergistically to worsen disease during co-infection. C-type lectin receptors (CLR) respond to pathogen-associated carbohydrates to activate downstream innate immunity and can be exploited for entry of intracellular pathogens. The macrophage (MΦ) galactose-type lectin (MGL, CLEC10A) is an immunomodulatory CLR associated with M2 MΦ. We previously described an immune role for a murine MGL homologue in an experimental model of tuberculosis (TB). Herein we extend these findings by identifying human MGL as an important member of the Mtb-responsive pathogen recognition receptor (PRR) repertoire that is activated in both M1 and M2 polarizing conditions. MΦ exposure to Mtb activates MGL expres"],"journal":["Frontiers in immunology"],"pagination":["1597281"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12522201"],"repository":["biostudies-literature"],"pubmed_title":["MGL/CLEC10A is an important C-type lectin receptor activated in the innate immune response to &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; and is suppressed in people with HIV."],"pmcid":["PMC12522201"],"pubmed_authors":["Chauhan S","Huante MB","Martinez-Martinez YB","Fan X","Gelman BB","Paez RN","Endsley MA","Naqvi KF","Lisinicchia JG","Nguyen H","Holloway AJ","Browning SE","Bharaj P","Endsley JJ"],"additional_accession":[]},"is_claimable":false,"name":"MGL/CLEC10A is an important C-type lectin receptor activated in the innate immune response to &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; and is suppressed in people with HIV.","description":"<i>Mycobacterium tuberculosis</i> (Mtb) and HIV are leading infectious causes of death worldwide and act synergistically to worsen disease during co-infection. C-type lectin receptors (CLR) respond to pathogen-associated carbohydrates to activate downstream innate immunity and can be exploited for entry of intracellular pathogens. The macrophage (MΦ) galactose-type lectin (MGL, CLEC10A) is an immunomodulatory CLR associated with M2 MΦ. We previously described an immune role for a murine MGL homologue in an experimental model of tuberculosis (TB). Herein we extend these findings by identifying human MGL as an important member of the Mtb-responsive pathogen recognition receptor (PRR) repertoire that is activated in both M1 and M2 polarizing conditions. MΦ exposure to Mtb activates MGL expres","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T12:04:38.108Z","creation":"2026-05-09T03:07:40.33Z"},"accession":"S-EPMC12522201","cross_references":{"pubmed":["41103425"],"doi":["10.3389/fimmu.2025.1597281"]}}