biostudies-literatureUnknown16Browning SE<i>Mycobacterium tuberculosis</i> (Mtb) and HIV are leading infectious causes of death worldwide and act synergistically to worsen disease during co-infection. C-type lectin receptors (CLR) respond to pathogen-associated carbohydrates to activate downstream innate immunity and can be exploited for entry of intracellular pathogens. The macrophage (MΦ) galactose-type lectin (MGL, CLEC10A) is an immunomodulatory CLR associated with M2 MΦ. We previously described an immune role for a murine MGL homologue in an experimental model of tuberculosis (TB). Herein we extend these findings by identifying human MGL as an important member of the Mtb-responsive pathogen recognition receptor (PRR) repertoire that is activated in both M1 and M2 polarizing conditions. MΦ exposure to Mtb activates MGL expresFrontiers in immunology1597281https://www.ebi.ac.uk/biostudies/studies/S-EPMC12522201biostudies-literatureMGL/CLEC10A is an important C-type lectin receptor activated in the innate immune response to <i>Mycobacterium tuberculosis</i> and is suppressed in people with HIV.PMC12522201Chauhan SHuante MBMartinez-Martinez YBFan XGelman BBPaez RNEndsley MANaqvi KFLisinicchia JGNguyen HHolloway AJBrowning SEBharaj PEndsley JJfalseMGL/CLEC10A is an important C-type lectin receptor activated in the innate immune response to <i>Mycobacterium tuberculosis</i> and is suppressed in people with HIV.<i>Mycobacterium tuberculosis</i> (Mtb) and HIV are leading infectious causes of death worldwide and act synergistically to worsen disease during co-infection. C-type lectin receptors (CLR) respond to pathogen-associated carbohydrates to activate downstream innate immunity and can be exploited for entry of intracellular pathogens. The macrophage (MΦ) galactose-type lectin (MGL, CLEC10A) is an immunomodulatory CLR associated with M2 MΦ. We previously described an immune role for a murine MGL homologue in an experimental model of tuberculosis (TB). Herein we extend these findings by identifying human MGL as an important member of the Mtb-responsive pathogen recognition receptor (PRR) repertoire that is activated in both M1 and M2 polarizing conditions. MΦ exposure to Mtb activates MGL expres2025-01-01T00:00:00Z20252026-06-04T12:04:38.108Z2026-05-09T03:07:40.33ZS-EPMC125222014110342510.3389/fimmu.2025.1597281