biostudies-literatureUnknown49Hallab A<h4>Introduction</h4>Therapy-resistant depression is associated with higher levels of systemic inflammation and increased odds of metabolic disorders. It is, therefore, crucial to identify the biomarkers of high-risk individuals and understand the key features of depression-immunometabolic networks.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Spearman's rank correlation network analysis was performed between immunological, metabolic, and subscales of the Geriatric Depression Scale (GDS). Significant correlations were then evaluated using a multivariable linear regression analysis, including testing for non-linearity and clinical cutoffs.<h4>Results</h4>Two clusters were formed: the first iBrain, behavior, & immunity - health101103https://www.ebi.ac.uk/biostudies/studies/S-EPMC12523063biostudies-literatureNetworks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression.PMC12523063Petersen MVardarajan BZhang FJohnson LHall JRLee JCheema ABarber RAnces BVig RMason DMielke MShi YMcColl RBabulal GHill CKing KBorzage MMindt MROkonkwo OLarge SLlibre-Guerra JHABS-HD InvestigatorsHallab AMapstone MChristian BHABS-HD MPIsKind APalmer RBarnes LRissman RBraskie MNandy RPhillips NDonohue MZhou ZRaman RCohen AO'Bryant SEYaffe KToga AVintimilla RHealth and Aging Brain Study (HABS-HD) Study TeamfalseNetworks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression.<h4>Introduction</h4>Therapy-resistant depression is associated with higher levels of systemic inflammation and increased odds of metabolic disorders. It is, therefore, crucial to identify the biomarkers of high-risk individuals and understand the key features of depression-immunometabolic networks.<h4>Methods</h4>The multiethnic ≥50-year-old study population is a subset of the Health and Aging Brain Study: Health Disparities (HABS-HD) study. Spearman's rank correlation network analysis was performed between immunological, metabolic, and subscales of the Geriatric Depression Scale (GDS). Significant correlations were then evaluated using a multivariable linear regression analysis, including testing for non-linearity and clinical cutoffs.<h4>Results</h4>Two clusters were formed: the first i2025-01-01T00:00:00Z2025 Nov2026-06-04T12:20:17.862Z2026-05-09T03:08:27.248ZS-EPMC125230634110435710.1016/j.bbih.2025.101103