biostudies-literatureIacovita CMinisterul Cercetării și Inovării9324https://www.ebi.ac.uk/biostudies/studies/S-EPMC12525091biostudies-literatureUnknown26(19)Surface functionalization of magnetic nanoparticles, commonly used for their biocompatibility in biomedical applications, plays a critical role in optimizing iron oxide nanoparticles (IONPs) for magnetic hyperthermia (MH), a promising modality in cancer therapy. In this study, we provide the first comprehensive comparison of hyperbranched dendron coatings versus linear dicarboxylate ligands on IONPs, revealing their contrasting impacts on heating efficiency under varying magnetic field amplitudes (H). Dendron-coated IONPs outperform dicarboxylate-coated ones at low fields (H < 25 kA/m) due to reduced dipolar interactions and enhanced Brownian relaxation. Conversely, dicarboxylate coatings excel at high fields (H > 25 kA/m) by enabling magnetically aligned chains, which amplify hysteresis lInternational journal of molecular sciencesComparative Influence of Dendron and Dicarboxylate Coatings on the Hyperthermia Performances of Cubic and Spherical Magnetic Nanoparticles.PMC12525091ERANET-EURONANOMED-THERAGETLucaciu CMKiefer CIacovita CFreis BBegin-Colin SfalseComparative Influence of Dendron and Dicarboxylate Coatings on the Hyperthermia Performances of Cubic and Spherical Magnetic Nanoparticles.Surface functionalization of magnetic nanoparticles, commonly used for their biocompatibility in biomedical applications, plays a critical role in optimizing iron oxide nanoparticles (IONPs) for magnetic hyperthermia (MH), a promising modality in cancer therapy. In this study, we provide the first comprehensive comparison of hyperbranched dendron coatings versus linear dicarboxylate ligands on IONPs, revealing their contrasting impacts on heating efficiency under varying magnetic field amplitudes (H). Dendron-coated IONPs outperform dicarboxylate-coated ones at low fields (H < 25 kA/m) due to reduced dipolar interactions and enhanced Brownian relaxation. Conversely, dicarboxylate coatings excel at high fields (H > 25 kA/m) by enabling magnetically aligned chains, which amplify hysteresis l2025-01-01T00:00:00Z2025 Sep2026-05-09T03:19:07.642Z2026-05-09T03:08:49.267ZS-EPMC125250914109659110.3390/ijms26199324