{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiu Y"],"funding":["Danqing Chen","Yunxian Yu"],"pagination":["3096"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12526048"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(19)"],"pubmed_abstract":["<b>Objective:</b> Vitamin D deficiency (VDD) is common in pregnancy and may affect lipid metabolism. The underlying mechanisms are multifactorial, but most evidence so far comes from non-pregnant populations. This study aims to identify metabolites and metabolic patterns associated with VDD in early pregnancy and to evaluate their relationships with maternal lipid profiles. <b>Methods:</b> A nested case-control research was carried out in the Zhoushan Pregnant Women Cohort (ZPWC). Cases were defined as women with VDD (25(OH)D < 20 ng/mL), and controls (≥20 ng/mL) were matched 1:1 using propensity scores based on age, pre-pregnancy BMI, gestational week, and calendar year at blood sampling. The untargeted metabolomics of first-trimester maternal plasma were measured. Metabolic profiles were"],"journal":["Nutrients"],"pubmed_title":["Alterations in the Metabolic and Lipid Profiles Associated with Vitamin D Deficiency in Early Pregnancy."],"pmcid":["PMC12526048"],"funding_grant_id":["2022YFC2703505","ZDFY2021-4X104","2021YFC2701901"],"pubmed_authors":["Qiu Y","Liu H","Xu N","Yu L","Wang B","Wang S","Alifu X","Cheng H","Chen D","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Alterations in the Metabolic and Lipid Profiles Associated with Vitamin D Deficiency in Early Pregnancy.","description":"<b>Objective:</b> Vitamin D deficiency (VDD) is common in pregnancy and may affect lipid metabolism. The underlying mechanisms are multifactorial, but most evidence so far comes from non-pregnant populations. This study aims to identify metabolites and metabolic patterns associated with VDD in early pregnancy and to evaluate their relationships with maternal lipid profiles. <b>Methods:</b> A nested case-control research was carried out in the Zhoushan Pregnant Women Cohort (ZPWC). Cases were defined as women with VDD (25(OH)D < 20 ng/mL), and controls (≥20 ng/mL) were matched 1:1 using propensity scores based on age, pre-pregnancy BMI, gestational week, and calendar year at blood sampling. The untargeted metabolomics of first-trimester maternal plasma were measured. Metabolic profiles were","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-09T03:18:35.769Z","creation":"2026-05-09T03:11:25.437Z"},"accession":"S-EPMC12526048","cross_references":{"pubmed":["41097173"],"doi":["10.3390/nu17193096"]}}