biostudies-literatureQiu YDanqing ChenYunxian Yu3096https://www.ebi.ac.uk/biostudies/studies/S-EPMC12526048biostudies-literatureUnknown17(19)<b>Objective:</b> Vitamin D deficiency (VDD) is common in pregnancy and may affect lipid metabolism. The underlying mechanisms are multifactorial, but most evidence so far comes from non-pregnant populations. This study aims to identify metabolites and metabolic patterns associated with VDD in early pregnancy and to evaluate their relationships with maternal lipid profiles. <b>Methods:</b> A nested case-control research was carried out in the Zhoushan Pregnant Women Cohort (ZPWC). Cases were defined as women with VDD (25(OH)D < 20 ng/mL), and controls (≥20 ng/mL) were matched 1:1 using propensity scores based on age, pre-pregnancy BMI, gestational week, and calendar year at blood sampling. The untargeted metabolomics of first-trimester maternal plasma were measured. Metabolic profiles wereNutrientsAlterations in the Metabolic and Lipid Profiles Associated with Vitamin D Deficiency in Early Pregnancy.PMC125260482022YFC2703505ZDFY2021-4X1042021YFC2701901Qiu YLiu HXu NYu LWang BWang SAlifu XCheng HChen DYu YfalseAlterations in the Metabolic and Lipid Profiles Associated with Vitamin D Deficiency in Early Pregnancy.<b>Objective:</b> Vitamin D deficiency (VDD) is common in pregnancy and may affect lipid metabolism. The underlying mechanisms are multifactorial, but most evidence so far comes from non-pregnant populations. This study aims to identify metabolites and metabolic patterns associated with VDD in early pregnancy and to evaluate their relationships with maternal lipid profiles. <b>Methods:</b> A nested case-control research was carried out in the Zhoushan Pregnant Women Cohort (ZPWC). Cases were defined as women with VDD (25(OH)D < 20 ng/mL), and controls (≥20 ng/mL) were matched 1:1 using propensity scores based on age, pre-pregnancy BMI, gestational week, and calendar year at blood sampling. The untargeted metabolomics of first-trimester maternal plasma were measured. Metabolic profiles were2025-01-01T00:00:00Z2025 Sep2026-05-09T03:18:35.769Z2026-05-09T03:11:25.437ZS-EPMC125260484109717310.3390/nu17193096