{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan L"],"funding":["Chinese National Natural Science Foundation"],"pagination":["1895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12528569"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive malignancy with poor prognosis and low five-year survival rates. Ferroptosis, an iron-dependent form of cell death, has emerged as a potential factor in cancer therapy. This study aimed to identify differentially expressed genes (DEGs) associated with HNSCC, ferroptosis, and radiotherapy, and to develop a diagnostic model to establish novel biomarkers, early diagnosis and individualized therapy.<h4>Methods</h4>We analyzed TCGA-HNSCC, GSE6631, and GSE107591 datasets to identify Ferroptosis- and Radiotherapy-Related Differentially Expressed Genes (F&RRDEGs).Ferroptosis & radiotherapy scores were calculated, followed by immune infiltration and immunotherapy analyses. A Cox prognostic model was evaluated using no"],"journal":["Discover oncology"],"pubmed_title":["Ferroptosis and radiotherapy-related genes in head and neck squamous cell carcinoma: diagnostic and prognostic significance."],"pmcid":["PMC12528569"],"funding_grant_id":["82071168"],"pubmed_authors":["Shi L","Mu Y","Fan L","Wang Z","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Ferroptosis and radiotherapy-related genes in head and neck squamous cell carcinoma: diagnostic and prognostic significance.","description":"<h4>Background</h4>Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive malignancy with poor prognosis and low five-year survival rates. Ferroptosis, an iron-dependent form of cell death, has emerged as a potential factor in cancer therapy. This study aimed to identify differentially expressed genes (DEGs) associated with HNSCC, ferroptosis, and radiotherapy, and to develop a diagnostic model to establish novel biomarkers, early diagnosis and individualized therapy.<h4>Methods</h4>We analyzed TCGA-HNSCC, GSE6631, and GSE107591 datasets to identify Ferroptosis- and Radiotherapy-Related Differentially Expressed Genes (F&RRDEGs).Ferroptosis & radiotherapy scores were calculated, followed by immune infiltration and immunotherapy analyses. A Cox prognostic model was evaluated using no","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T14:37:20.39Z","creation":"2026-07-06T03:08:43.48Z"},"accession":"S-EPMC12528569","cross_references":{"pubmed":["41091342"],"doi":["10.1007/s12672-025-03713-7"]}}