biostudies-literatureUnknown16Du Q<h4>Aim</h4>The efficacy of intravenous alteplase thrombolysis in patients with minor non-disabling acute ischemic stroke with severe large vessel stenosis or occlusion remains uncertain. This study aimed to assess the clinical effectiveness of intravenous alteplase therapy compared to dual antiplatelet therapy (DAPT) in this specific high-risk population.<h4>Methods</h4>We conducted a retrospective study of patients presenting with minor non-disabling strokes [National Institutes of Health Stroke Scale (NIHSS) score ≤ 5 with all item scores 0 or 1] and severe large vessel stenosis or occlusion across four hospitals in Yichang City, Hubei Province (January 2019-December 2024, <i>n</i> = 396). Propensity score matching (1:1 nearest-neighbor with caliper 0.2 SD) was performed to balance baseFrontiers in neurology1661549https://www.ebi.ac.uk/biostudies/studies/S-EPMC12531376biostudies-literatureEvaluating the effectiveness of intravenous alteplase in patients with minor non-disabling stroke and severe large vessel stenosis: a retrospective study.PMC12531376Liu XLi XDu QLiu ZHuang ZHou HYan YXu HTang YfalseEvaluating the effectiveness of intravenous alteplase in patients with minor non-disabling stroke and severe large vessel stenosis: a retrospective study.<h4>Aim</h4>The efficacy of intravenous alteplase thrombolysis in patients with minor non-disabling acute ischemic stroke with severe large vessel stenosis or occlusion remains uncertain. This study aimed to assess the clinical effectiveness of intravenous alteplase therapy compared to dual antiplatelet therapy (DAPT) in this specific high-risk population.<h4>Methods</h4>We conducted a retrospective study of patients presenting with minor non-disabling strokes [National Institutes of Health Stroke Scale (NIHSS) score ≤ 5 with all item scores 0 or 1] and severe large vessel stenosis or occlusion across four hospitals in Yichang City, Hubei Province (January 2019-December 2024, <i>n</i> = 396). Propensity score matching (1:1 nearest-neighbor with caliper 0.2 SD) was performed to balance base2025-01-01T00:00:00Z20252026-06-04T14:25:54.098Z2026-05-10T03:11:27.453ZS-EPMC125313764111197210.3389/fneur.2025.1661549