biostudies-literatureUnknown8(10)Sato K<h4>Importance</h4>Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium reduction, but evidence remains limited.<h4>Objective</h4>To evaluate the effectiveness of a sodium reduction program incorporating a genetic profile and an artificial intelligence (AI)-based mobile app among adults with elevated blood pressure and a sodium-sensitive genotype.<h4>Design, setting, and participants</h4>A 3-arm randomized clinical trial, conducted at a Japanese electronics company from September 17 to December 16, 2024, included employees aged 20 to 65 years with elevated blood pressure and the sodium-sensitive AGT M235T genotype.<h4>InterJAMA network opene2537540https://www.ebi.ac.uk/biostudies/studies/S-EPMC12531883biostudies-literatureSodium Reduction Program Incorporating Genetic Profile and an AI-Based App: A Randomized Clinical Trial.PMC12531883Yanagisawa TYagi MYamaguchi TMizuno SNode KAkiyama NKondo NSato KInoue KFurukawa TAEbisawa MfalseSodium Reduction Program Incorporating Genetic Profile and an AI-Based App: A Randomized Clinical Trial.<h4>Importance</h4>Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium reduction, but evidence remains limited.<h4>Objective</h4>To evaluate the effectiveness of a sodium reduction program incorporating a genetic profile and an artificial intelligence (AI)-based mobile app among adults with elevated blood pressure and a sodium-sensitive genotype.<h4>Design, setting, and participants</h4>A 3-arm randomized clinical trial, conducted at a Japanese electronics company from September 17 to December 16, 2024, included employees aged 20 to 65 years with elevated blood pressure and the sodium-sensitive AGT M235T genotype.<h4>Inter2025-01-01T00:00:00Z2025 Oct2026-07-15T12:08:54.686Z2026-07-04T03:11:54.264ZS-EPMC125318834110008610.1001/jamanetworkopen.2025.37540