biostudies-literatureMo AMonash UniversityNational Blood AuthorityNational Health and Medical Research CouncilHaematology Society of Australia and New Zealand1803-1809https://www.ebi.ac.uk/biostudies/studies/S-EPMC12531908biostudies-literatureUnknown65(10)<h4>Background</h4>Evidence guiding optimal transfusion practice for patients with myelodysplastic syndromes (MDS) is lacking. Many patients have concurrent cardiac disease. Data on practice are sparse. We aimed to describe the use of red blood cell (RBC) transfusion and the prevalence of cardiac comorbidities in patients with MDS within Australia's largest public hospital network to better understand real-world practices and outcomes.<h4>Methods</h4>We conducted a retrospective cohort study of patients aged ≥18 years with MDS, MDS/myeloproliferative overlap neoplasm or chronic myelomonocytic leukemia admitted from 2016 to 2018 to determine RBC transfusion-related endpoints.<h4>Results</h4>One hundred and seventy-nine patients (median age 78 years, 61.5% male) were included, with a median TransfusionRed blood cell transfusion practice and cardiac comorbidities in patients with myelodysplastic syndromes.PMC12531908200917711948111177784APP1151512Shortt JMcQuilten ZKMo AWood EMfalseRed blood cell transfusion practice and cardiac comorbidities in patients with myelodysplastic syndromes.<h4>Background</h4>Evidence guiding optimal transfusion practice for patients with myelodysplastic syndromes (MDS) is lacking. Many patients have concurrent cardiac disease. Data on practice are sparse. We aimed to describe the use of red blood cell (RBC) transfusion and the prevalence of cardiac comorbidities in patients with MDS within Australia's largest public hospital network to better understand real-world practices and outcomes.<h4>Methods</h4>We conducted a retrospective cohort study of patients aged ≥18 years with MDS, MDS/myeloproliferative overlap neoplasm or chronic myelomonocytic leukemia admitted from 2016 to 2018 to determine RBC transfusion-related endpoints.<h4>Results</h4>One hundred and seventy-nine patients (median age 78 years, 61.5% male) were included, with a median 2025-01-01T00:00:00Z2025 Oct2026-06-04T14:11:54.824Z2026-05-10T03:11:08.523ZS-EPMC125319084087876710.1111/trf.18391