biostudies-literatureUnknown15(46)Elgohary MKThis study aimed to discover novel multifunctional anticonvulsant agents through the evaluation of a series of test compounds 5d-f, 7b, and 10c-f, which were previously identified based on their potent anti-inflammatory activity in both <i>in vitro</i> and <i>in vivo</i> models in acute and chronic seizure models. Initial screening in the pentylenetetrazol (PTZ)-induced seizure model identified compounds 7b, 5f, 5e, and 10c as the most effective, with compound 7b demonstrating complete seizure protection (100%) and zero mortality, outperforming the reference drug valproic acid (VI). These four candidates were further assessed in the pilocarpine-induced temporal lobe epilepsy model. Compound 7b again showed superior efficacy, significantly delaying seizure onset by 188.6%, reducing seizure RSC advances39161-39179https://www.ebi.ac.uk/biostudies/studies/S-EPMC12531995biostudies-literatureDiscovery and characterization of phenoxyacetic acid derivatives as potential antiepileptic agents.PMC12531995Abdel-Aziz HANaglah AMFares MEldehna WMAlmehizia AAAlqarni MHElgohary MKAlkabbani MAElkotamy MSfalseDiscovery and characterization of phenoxyacetic acid derivatives as potential antiepileptic agents.This study aimed to discover novel multifunctional anticonvulsant agents through the evaluation of a series of test compounds 5d-f, 7b, and 10c-f, which were previously identified based on their potent anti-inflammatory activity in both <i>in vitro</i> and <i>in vivo</i> models in acute and chronic seizure models. Initial screening in the pentylenetetrazol (PTZ)-induced seizure model identified compounds 7b, 5f, 5e, and 10c as the most effective, with compound 7b demonstrating complete seizure protection (100%) and zero mortality, outperforming the reference drug valproic acid (VI). These four candidates were further assessed in the pilocarpine-induced temporal lobe epilepsy model. Compound 7b again showed superior efficacy, significantly delaying seizure onset by 188.6%, reducing seizure 2025-01-01T00:00:00Z2025 Oct2026-06-04T14:12:19.943Z2026-05-10T03:11:14.316ZS-EPMC125319954111360210.1039/d5ra05596b