{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["Natural Science Foundation of Fujian Province","National Natural Science Foundation of China","Science Fund for Distinguished Young Scholars of Fujian Province","Science Fund from the Health Commission of Fujian"],"pagination":["1116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12532471"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Chelerythrine (CHE) exhibits notable anti-inflammatory and antitumor properties, while its impact on esophageal squamous cell carcinoma (ESCC), especially the underlying mechanisms remain unclear. In this study, we aim to investigate the roles and mechanism of CHE in the ESCC treatment.<h4>Methods</h4>Human ESCC cell lines and organoids were used for in vitro cell experiments, BALB/c nude mice were used for in vivo animal experiments. To investigate the underlying mechanism of CHE treatment, drug library screen, RNA sequencing analysis, TMT-based quantitative proteomic analysis, western blotting analysis, immunofluorescence, immunohistochemistry, quantitative real-time polymerase chain reaction, mitochondrial membrane potential assay, apoptosis assay, detection of mitoch"],"journal":["Journal of translational medicine"],"pubmed_title":["Chelerythrine inhibits esophageal squamous cell carcinoma progression via PINK1-Parkin-mediated mitophagy."],"pmcid":["PMC12532471"],"funding_grant_id":["2021D034","82273044","2023GGB04","2023J01015"],"pubmed_authors":["Liu K","Zhang K","Zhang J","Shi S","Lin Y","Zhang L","Zhou Y","Liu Y","Li X","Xie J","An X","Wang Z","Zhang B","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Chelerythrine inhibits esophageal squamous cell carcinoma progression via PINK1-Parkin-mediated mitophagy.","description":"<h4>Background</h4>Chelerythrine (CHE) exhibits notable anti-inflammatory and antitumor properties, while its impact on esophageal squamous cell carcinoma (ESCC), especially the underlying mechanisms remain unclear. In this study, we aim to investigate the roles and mechanism of CHE in the ESCC treatment.<h4>Methods</h4>Human ESCC cell lines and organoids were used for in vitro cell experiments, BALB/c nude mice were used for in vivo animal experiments. To investigate the underlying mechanism of CHE treatment, drug library screen, RNA sequencing analysis, TMT-based quantitative proteomic analysis, western blotting analysis, immunofluorescence, immunohistochemistry, quantitative real-time polymerase chain reaction, mitochondrial membrane potential assay, apoptosis assay, detection of mitoch","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T14:28:33.51Z","creation":"2026-05-10T03:11:21.221Z"},"accession":"S-EPMC12532471","cross_references":{"pubmed":["41107946"],"doi":["10.1186/s12967-025-07025-w"]}}