biostudies-literatureUnknown25(1)Yao L<h4>Background</h4>Evidence concerning the association between excessive total bile acid (TBA) concentrations and adverse perinatal outcomes in the recent Chinese guidelines for intrahepatic cholestasis of pregnancy (C-ICP), which recommend including asymptomatic hypercholanemia of pregnancy (AHP) in ICP management, is insufficient. This study aims to investigate the association between adverse perinatal outcomes and maternal TBA concentrations in patients with C-ICP and compare differences in adverse perinatal outcomes between AHP and ICP subgroups in different TBA concentrations.<h4>Methods</h4>This retrospective cohort study included pregnant individuals with C-ICP (n = 957) who delivered and had regular antenatal examination records available at a hospital in Guangzhou, China, from JanBMC pregnancy and childbirth1103https://www.ebi.ac.uk/biostudies/studies/S-EPMC12532476biostudies-literatureTotal bile acid concentrations and adverse perinatal outcomes in chinese intrahepatic cholestasis of pregnancy including asymptomatic hypercholanemia of pregnancy: a retrospective cohort study.PMC12532476Yao LYin YHe TLi CTan ZZhou JZhang PfalseTotal bile acid concentrations and adverse perinatal outcomes in chinese intrahepatic cholestasis of pregnancy including asymptomatic hypercholanemia of pregnancy: a retrospective cohort study.<h4>Background</h4>Evidence concerning the association between excessive total bile acid (TBA) concentrations and adverse perinatal outcomes in the recent Chinese guidelines for intrahepatic cholestasis of pregnancy (C-ICP), which recommend including asymptomatic hypercholanemia of pregnancy (AHP) in ICP management, is insufficient. This study aims to investigate the association between adverse perinatal outcomes and maternal TBA concentrations in patients with C-ICP and compare differences in adverse perinatal outcomes between AHP and ICP subgroups in different TBA concentrations.<h4>Methods</h4>This retrospective cohort study included pregnant individuals with C-ICP (n = 957) who delivered and had regular antenatal examination records available at a hospital in Guangzhou, China, from Jan2025-01-01T00:00:00Z2025 Oct2026-06-04T13:47:16.28Z2026-05-09T03:12:18.407ZS-EPMC125324764110271710.1186/s12884-025-08085-y