{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(5)"],"submitter":["Jeong JJ"],"funding":["Seoul National University"],"pubmed_abstract":["Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study is to demonstrate the effect of multistrain probiotics (Sensi-Biome) on diarrhea from the perspective of the microbiome-neuron axis. Sensi-Biome (Lactiplantibacillus plantarum, Bifidobacterium animalis subsp. lactis, Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium bifidum, and Lactococcus lactis) was administered in a 4% acetic acid-induced diarrhea rat model at concentrations of 1 × 10<sup>8</sup> (G1), 1 × 10<sup>9</sup> (G2), and 1 × 10<sup>10</sup> CFU/0.5 mL (G3). Diarrhea-related parameters, inflammation-related cytokines, and stool microbiota analysis by 16S rRNA were evaluated. A targeted and untargeted metabolomics approach was u"],"journal":["Probiotics and antimicrobial proteins"],"pagination":["2894-2908"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12532644"],"repository":["biostudies-literature"],"pubmed_title":["Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway."],"pmcid":["PMC12532644"],"pubmed_authors":["Jeong JJ","Yoon SJ","Jin YJ","Jeong MK","Choi MR","Lim JH","Lee DY","Suk KT","Han SH","Park HJ","Min U","Min BH","Choi J","Jang YJ","Ganesan R","Sharma SP","Na KM","Ham YL","Kim BY"],"additional_accession":[]},"is_claimable":false,"name":"Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway.","description":"Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study is to demonstrate the effect of multistrain probiotics (Sensi-Biome) on diarrhea from the perspective of the microbiome-neuron axis. Sensi-Biome (Lactiplantibacillus plantarum, Bifidobacterium animalis subsp. lactis, Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium bifidum, and Lactococcus lactis) was administered in a 4% acetic acid-induced diarrhea rat model at concentrations of 1 × 10<sup>8</sup> (G1), 1 × 10<sup>9</sup> (G2), and 1 × 10<sup>10</sup> CFU/0.5 mL (G3). Diarrhea-related parameters, inflammation-related cytokines, and stool microbiota analysis by 16S rRNA were evaluated. A targeted and untargeted metabolomics approach was u","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T14:34:56.172Z","creation":"2026-05-10T03:11:20.755Z"},"accession":"S-EPMC12532644","cross_references":{"pubmed":["38467925"],"doi":["10.1007/s12602-024-10232-4"]}}