{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Yu-Ping Peng","Yi-Hua Qiu"],"pagination":["194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12532925"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["Background
β2-adrenergic receptor (β2-AR) is widely expressed on immune cells, including T cells and it has a non-canonical signaling pathway, which is β2-AR-β-arrestin 2 (β-Arr2)-extracellular signal-regulated kinase 1/2 (ERK1/2). Our previous studies have shown that the β2-AR agonist terbutaline (Terb) can activate β2-AR and significantly inhibit helper T (Th) 17 cell function in collagen-induced arthritis (CIA). However, the effects of β2-AR on regulatory T (Treg) cells in CIA have not been consistently determined. The aim of our research was to explore whether β2-AR-β-Arr2-ERK1/2 signaling in Treg cells regulates inflammatory responses and signs in CIA.Methods
DBA1/J mice were used to prepare CIA model by intradermal injection of collagen type II (CII). Inducible Treg ("],"journal":["Arthritis research & therapy"],"pubmed_title":["Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis."],"pmcid":["PMC12532925"],"funding_grant_id":["31771293","31371182"],"pubmed_authors":["Peng YP","Liu Y","Lu JH","Huang HW","Wang XQ","Qiu YH"],"additional_accession":[]},"is_claimable":false,"name":"Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis.","description":"Background
β2-adrenergic receptor (β2-AR) is widely expressed on immune cells, including T cells and it has a non-canonical signaling pathway, which is β2-AR-β-arrestin 2 (β-Arr2)-extracellular signal-regulated kinase 1/2 (ERK1/2). Our previous studies have shown that the β2-AR agonist terbutaline (Terb) can activate β2-AR and significantly inhibit helper T (Th) 17 cell function in collagen-induced arthritis (CIA). However, the effects of β2-AR on regulatory T (Treg) cells in CIA have not been consistently determined. The aim of our research was to explore whether β2-AR-β-Arr2-ERK1/2 signaling in Treg cells regulates inflammatory responses and signs in CIA.Methods
DBA1/J mice were used to prepare CIA model by intradermal injection of collagen type II (CII). Inducible Treg (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-10T03:21:44.747Z","creation":"2026-05-10T03:11:17.735Z"},"accession":"S-EPMC12532925","cross_references":{"pubmed":["41107955"],"doi":["10.1186/s13075-025-03659-9"]}}