biostudies-literatureLiu YYu-Ping PengYi-Hua Qiu194https://www.ebi.ac.uk/biostudies/studies/S-EPMC12532925biostudies-literatureUnknown27(1)<h4>Background</h4>β2-adrenergic receptor (β2-AR) is widely expressed on immune cells, including T cells and it has a non-canonical signaling pathway, which is β2-AR-β-arrestin 2 (β-Arr2)-extracellular signal-regulated kinase 1/2 (ERK1/2). Our previous studies have shown that the β2-AR agonist terbutaline (Terb) can activate β2-AR and significantly inhibit helper T (Th) 17 cell function in collagen-induced arthritis (CIA). However, the effects of β2-AR on regulatory T (Treg) cells in CIA have not been consistently determined. The aim of our research was to explore whether β2-AR-β-Arr2-ERK1/2 signaling in Treg cells regulates inflammatory responses and signs in CIA.<h4>Methods</h4>DBA1/J mice were used to prepare CIA model by intradermal injection of collagen type II (CII). Inducible Treg (Arthritis research & therapyTreg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis.PMC125329253177129331371182Peng YPLiu YLu JHHuang HWWang XQQiu YHfalseTreg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis.<h4>Background</h4>β2-adrenergic receptor (β2-AR) is widely expressed on immune cells, including T cells and it has a non-canonical signaling pathway, which is β2-AR-β-arrestin 2 (β-Arr2)-extracellular signal-regulated kinase 1/2 (ERK1/2). Our previous studies have shown that the β2-AR agonist terbutaline (Terb) can activate β2-AR and significantly inhibit helper T (Th) 17 cell function in collagen-induced arthritis (CIA). However, the effects of β2-AR on regulatory T (Treg) cells in CIA have not been consistently determined. The aim of our research was to explore whether β2-AR-β-Arr2-ERK1/2 signaling in Treg cells regulates inflammatory responses and signs in CIA.<h4>Methods</h4>DBA1/J mice were used to prepare CIA model by intradermal injection of collagen type II (CII). Inducible Treg (2025-01-01T00:00:00Z2025 Oct2026-05-10T03:21:44.747Z2026-05-10T03:11:17.735ZS-EPMC125329254110795510.1186/s13075-025-03659-9