{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(10)"],"submitter":["Gutierrez-Gonzalez JA"],"pubmed_abstract":["An infusion of Ageratina grandifolia, a traditional preparation, and major compounds [3,5-diprenyl-4-hydroxyacetophenone (1), O-methylencecalinol (2), encecalin (3), and encecalinol (4)], tested at 10, 31.6, and 100 mg/kg, intragastrically administered, showed a significant antinociceptive effect in both phases of the formalin test in mice. Encecalinol (4) was the most active and showed a dose-dependent antinociceptive action in both phases; its effect was substantially attenuated when the mice were pretreated with naloxone. The volatile constituents of A. grandifolia, A. petiolaris, and A. espinosarum were established through gas chromatography-mass spectrometry analysis of the components obtained by head-space solid microextraction and hydrodistillation. The volatiles contained a high pe"],"journal":["Chemistry & biodiversity"],"pagination":["e00287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12533799"],"repository":["biostudies-literature"],"pubmed_title":["Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob."],"pmcid":["PMC12533799"],"pubmed_authors":["Martinez AL","Mata R","Garcia-Marin G","Rivero-Cruz I","Villasenor JL","Gutierrez-Gonzalez JA"],"additional_accession":[]},"is_claimable":false,"name":"Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob.","description":"An infusion of Ageratina grandifolia, a traditional preparation, and major compounds [3,5-diprenyl-4-hydroxyacetophenone (1), O-methylencecalinol (2), encecalin (3), and encecalinol (4)], tested at 10, 31.6, and 100 mg/kg, intragastrically administered, showed a significant antinociceptive effect in both phases of the formalin test in mice. Encecalinol (4) was the most active and showed a dose-dependent antinociceptive action in both phases; its effect was substantially attenuated when the mice were pretreated with naloxone. The volatile constituents of A. grandifolia, A. petiolaris, and A. espinosarum were established through gas chromatography-mass spectrometry analysis of the components obtained by head-space solid microextraction and hydrodistillation. The volatiles contained a high pe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T14:32:25.83Z","creation":"2026-05-10T03:11:11.375Z"},"accession":"S-EPMC12533799","cross_references":{"pubmed":["40468770"],"doi":["10.1002/cbdv.202500287"]}}