biostudies-literatureLiang ZShenzhen Key Medical Discipline Construction FundNational Key Clinical Specialty Construction Project and the National Nature Science Foundation of China Projecte0334719https://www.ebi.ac.uk/biostudies/studies/S-EPMC12533892biostudies-literatureUnknown20(10)As a major global health concern, Gastroesophageal Reflux Disease (GERD) has garnered widespread attention; However, to date, the prevalence of GERD across different ethnic groups in China has not been comprehensively examined by any large-scale epidemiological studies or meta-analyses. Against this backdrop, the present study draws on data from the Global Burden of Disease (GBD) Study to investigate the burden of GERD in China. Data from the 2021 GBD Study were utilized to assess the burden of GERD in China, focusing on key indicators such as prevalence, incidence, Years of Life Lived with Disability (YLDs), Age-Standardized Rates (ASR). Health inequality analyses were used to measure the inequality in the distribution of GERD across countries based on the Socio-Demographic Index (SDI), aPloS oneBurdens of Gastroesophageal Reflux Disease in China: Findings from the 2021 GBD Study.PMC125338928217279081973858SZXK015Zeng BWu JJiang ZHou ZLi YLiang ZLi FYu ZfalseBurdens of Gastroesophageal Reflux Disease in China: Findings from the 2021 GBD Study.As a major global health concern, Gastroesophageal Reflux Disease (GERD) has garnered widespread attention; However, to date, the prevalence of GERD across different ethnic groups in China has not been comprehensively examined by any large-scale epidemiological studies or meta-analyses. Against this backdrop, the present study draws on data from the Global Burden of Disease (GBD) Study to investigate the burden of GERD in China. Data from the 2021 GBD Study were utilized to assess the burden of GERD in China, focusing on key indicators such as prevalence, incidence, Years of Life Lived with Disability (YLDs), Age-Standardized Rates (ASR). Health inequality analyses were used to measure the inequality in the distribution of GERD across countries based on the Socio-Demographic Index (SDI), a2025-01-01T00:00:00Z20252026-05-10T03:21:03.417Z2026-05-10T03:11:19.629ZS-EPMC125338924110564910.1371/journal.pone.0334719