{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salmond N"],"funding":["NSERC Discovery Grants Program"],"pagination":["326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12534435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Diagnosis of stage 1 breast cancer is challenging as small tumors are often left undetected by conventional imaging techniques. In addition, ~80% of detected breast masses are classified as benign, which means that a large proportion of diagnostic needle biopsies lead to unnecessary psychological stress and medical costs. We investigated circulating extracellular vesicles (EVs) as potential carriers of unique cancer-associated proteins capable of reporting on a breast cancer diagnosis. We isolated EVs from healthy (19), benign (19), and stage 1 breast cancer patient (86) plasma samples using size exclusion chromatography. Mass spectrometry identified 94 significantly changed proteins in the plasma EVs from breast cancer patients. Analysis of a subset of these proteins using a cohort of pre"],"journal":["NPJ precision oncology"],"pubmed_title":["Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer."],"pmcid":["PMC12534435"],"funding_grant_id":["RGPIN-04641"],"pubmed_authors":["Moravcova R","Brackstone M","Watson PH","Lynn K","Salmond N","Williams KC","Rogalski JC","Tam WS","Khanna K"],"additional_accession":[]},"is_claimable":false,"name":"Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer.","description":"Diagnosis of stage 1 breast cancer is challenging as small tumors are often left undetected by conventional imaging techniques. In addition, ~80% of detected breast masses are classified as benign, which means that a large proportion of diagnostic needle biopsies lead to unnecessary psychological stress and medical costs. We investigated circulating extracellular vesicles (EVs) as potential carriers of unique cancer-associated proteins capable of reporting on a breast cancer diagnosis. We isolated EVs from healthy (19), benign (19), and stage 1 breast cancer patient (86) plasma samples using size exclusion chromatography. Mass spectrometry identified 94 significantly changed proteins in the plasma EVs from breast cancer patients. Analysis of a subset of these proteins using a cohort of pre","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T13:50:01.672Z","creation":"2026-05-09T03:11:59.834Z"},"accession":"S-EPMC12534435","cross_references":{"pubmed":["41107443"],"doi":["10.1038/s41698-025-01109-y"]}}