{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(9)"],"submitter":["Wang Z"],"pubmed_abstract":["Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild boars from Eastern Asia, Central Asia, and Europe, combined with 49 existing genomes, creating a comprehensive dataset of 96 individuals. Our analyses show that Asian wild boars and Southeast Asian Suids split ∼3.6 million years ago (mya), with Central Asian and Southern Chinese ancestors diverging ∼1.8 mya. The split between Central Asian and European-Near East ancestors occurred ∼0.9 mya, followed by a European-Near East divergence ∼0.6 mya. We identify signatures of local adaptation in Central Asian populations, including two positively selected variants in LPIN1, associated with lipid metabolism, and a missense mutation in ALPK2, linked to meat traits. These findings provide insights into wild boar dispersal and adaptation and shed light on domestic pig breeding."],"journal":["Cell genomics"],"pagination":["100954"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12534701"],"repository":["biostudies-literature"],"pubmed_title":["Genomic insights into the demographic history and local adaptation of wild boars across Eurasia."],"pmcid":["PMC12534701"],"pubmed_authors":["Zhang D","Xu P","Madsen O","Chen J","Groenen MAM","Song C","Li K","Yin H","Li Z","Huang T","Zhao S","Qiao R","Zhang Y","Bai L","Liu D","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Genomic insights into the demographic history and local adaptation of wild boars across Eurasia.","description":"Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild boars from Eastern Asia, Central Asia, and Europe, combined with 49 existing genomes, creating a comprehensive dataset of 96 individuals. Our analyses show that Asian wild boars and Southeast Asian Suids split ∼3.6 million years ago (mya), with Central Asian and Southern Chinese ancestors diverging ∼1.8 mya. The split between Central Asian and European-Near East ancestors occurred ∼0.9 mya, followed by a European-Near East divergence ∼0.6 mya. We identify signatures of local adaptation in Central Asian populations, including two positively selected variants in LPIN1, associated with lipid metabolism, and a missense mutation in ALPK2, linked to meat traits. These findings provide insights into wild boar dispersal and adaptation and shed light on domestic pig breeding.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T14:35:00.02Z","creation":"2026-05-10T03:11:21.137Z"},"accession":"S-EPMC12534701","cross_references":{"pubmed":["40712570"],"doi":["10.1016/j.xgen.2025.100954"]}}