biostudies-literatureUnknown30(30)Tandon S<h4>Background</h4>F-18 flurpiridaz is a novel radiotracer approved for positron emission tmography (PET) myocardial perfusion imaging. Its long half-life supports exercise stress testing, and its short positron range and high myocardial extraction fraction provide superior image resolution.<h4>Early reports summary</h4>A 70-year-old man with known coronary artery disease and prior coronary revascularization underwent exercise cardiac PET with F-18 flurpiridaz for chest discomfort. PET showed ischemia in the left anterior descending and right coronary artery territories. Coronary angiography revealed a severe mid-left anterior descending lesion and a severe proximal lesion in a small-caliber right posterior descending artery.<h4>Discussion</h4>Ischemia on PET correlated with coronary angioJACC. Case reports105279https://www.ebi.ac.uk/biostudies/studies/S-EPMC12540280biostudies-literatureFirst Post-Approval Clinical Use of F-18 Flurpiridaz With Exercise Cardiac PET in the United States.PMC12540280Khalique OKTandon SChen LQfalseFirst Post-Approval Clinical Use of F-18 Flurpiridaz With Exercise Cardiac PET in the United States.<h4>Background</h4>F-18 flurpiridaz is a novel radiotracer approved for positron emission tmography (PET) myocardial perfusion imaging. Its long half-life supports exercise stress testing, and its short positron range and high myocardial extraction fraction provide superior image resolution.<h4>Early reports summary</h4>A 70-year-old man with known coronary artery disease and prior coronary revascularization underwent exercise cardiac PET with F-18 flurpiridaz for chest discomfort. PET showed ischemia in the left anterior descending and right coronary artery territories. Coronary angiography revealed a severe mid-left anterior descending lesion and a severe proximal lesion in a small-caliber right posterior descending artery.<h4>Discussion</h4>Ischemia on PET correlated with coronary angio2025-01-01T00:00:00Z2025 Oct2026-06-02T03:13:16.136Z2026-06-02T03:09:04.225ZS-EPMC125402804104390910.1016/j.jaccas.2025.105279